Design and operation of a continuous integrated monoclonal antibody production process, Biotechnol. Prog.
End-to-end integrated continuous mAb manufacturing combines perfusion culture, CaptureSMB capture, virus inactivation, and MCSGP polishing.
RESOURCE LIBRARY
The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.
The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.
Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)
First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.
Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)
Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.
Müller et al.
Biotechnol. Bioeng. (Open-Access)
Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.
End-to-end integrated continuous mAb manufacturing combines perfusion culture, CaptureSMB capture, virus inactivation, and MCSGP polishing.
A continuous downstream process of monoclonal antibody was developed, the process was found to be flexible and stable for feed fluctuations.
Development and implementation of a twin-column MCSGP process for Liraglutide purification using simulation and optimization approaches.
Experimental design methodology for twin-column MCSGP processes establishes systematic approaches for process development and optimization.
Optimal model-based design methodology for CaptureSMB demonstrates improved capacity utilization and productivity compared to empirical design approaches.
Analysis of process performance and product quality across integrated continuous mAb production demonstrates stable operation under varying conditions.
A practical primer on chromatography: what it is, how it works, and why it matters. Learn about key separation mechanisms including reversed-phase, ion exchange, size exclusion and affinity chromatography, plus how to read chromatograms and the difference between analytical and preparative methods.
YMC ChromaCon Chromatography Newsletter.
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