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Application Notes, Webinars & Papers

The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.

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Recent MCSGP Research Highlights

The first peer-reviewed PC/PPQ framework for MCSGP

The first peer-reviewed PC/PPQ framework for MCSGP

The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.

Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)

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First peer-reviewed AIEX MCSGP for therapeutic siRNA

First peer-reviewed AIEX MCSGP for therapeutic siRNA

First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.

Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)

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Proof-of-concept MCSGP for AAV2 polishing

Proof-of-concept MCSGP for AAV2 polishing

Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.

Müller et al.
Biotechnol. Bioeng. (Open-Access)

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Resource Library

Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.

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MCSGP Process Development – Part 2: MCSGP Optimization
Application Notes 16 Feb 2026 English

MCSGP Process Development – Part 2: MCSGP Optimization

This application note presents a systematic approach for optimization of MCSGP with regards to the performance parameters Yield, Productivity and Eluent Consumption, and gives recommendations on the priority of the parameters.

Continuous Polishing (MCSGP) Dynamic Process Control (AutoPeak® & AutomAb®) Oligonucleotides Small Molecules & Nutraceuticals Antibody-drug Conjugates Peptides Recombinant Proteins Viral Vectors (AAV)
Purification of a Therapeutic Oligonucleotide Using Twin-Column Chromatography (MCSGP)
Application Notes 16 Feb 2026 English

Purification of a Therapeutic Oligonucleotide Using Twin-Column Chromatography (MCSGP)

This application note demonstrates a significant improvement in yield and productivity by converting an optimized batch chromatography method to Multi-column Counter-current Solvent Gradient Purification (MCSGP) for the manufacturing of a therapeutic oligonucleotide.

Continuous Polishing (MCSGP) Dynamic Process Control (AutoPeak® & AutomAb®) Contichrom® CUBE Oligonucleotides
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Educational Articles

Part I – What Is Chromatography? The Universal Primer for New Scientists
Fundamentals of Preparative Chromatography 25 Nov 2025

Part I – What Is Chromatography? The Universal Primer for New Scientists

A practical primer on chromatography: what it is, how it works, and why it matters. Learn about key separation mechanisms including reversed-phase, ion exchange, size exclusion and affinity chromatography, plus how to read chromatograms and the difference between analytical and preparative methods.

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