Continuous Chromatography Resource Library

Application Notes, Webinars & Papers

The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.

Recent MCSGP Research Highlights

The first peer-reviewed PC/PPQ framework for MCSGP

The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.

Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)

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First peer-reviewed AIEX MCSGP for therapeutic siRNA

First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.

Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)

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Proof-of-concept MCSGP for AAV2 polishing

Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.

Müller et al.
Biotechnol. Bioeng. (Open-Access)

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Resource Library

Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.

Brochures & Datasheets 04 Dec 2025 English

Contichrom CUBE Brochure

Batch Chromatography Continuous Capture (CaptureSMB®) Continuous Enrichment (N-Rich®) Continuous Polishing (MCSGP) Dynamic Process Control (AutoPeak® & AutomAb®) Multi-Dimensional Chromatography (2D/3D) System Rentals Demos & Introductions Contichrom® CUBE Antibody-drug Conjugates Impurity Isolation mAbs & Antibody Variants Small Molecules & Nutraceuticals Oligonucleotides Recombinant Proteins Peptides Viral Vectors (AAV)

Brochures & Datasheets 03 Dec 2025 English

Contichrom PILOT 300X Brochure

Overview of the technical specifications and functionalities offered by the Contichrom PILOT 300X

Continuous Polishing (MCSGP) Dynamic Process Control (AutoPeak® & AutomAb®) Multi-Dimensional Chromatography (2D/3D) Batch Chromatography Contichrom® PILOT Oligonucleotides Peptides Small Molecules & Nutraceuticals

Peer-Reviewed Publications 15 Oct 2024 English

Integrated multidimensional chromatography on preparative scale for oligonucleotides purification, J. Chromatogr. A

Integrated multidimensional chromatography combining different separation modes enables comprehensive oligonucleotide purification at preparative scale.

Multi-Dimensional Chromatography (2D/3D) Contichrom® CUBE Oligonucleotides

Peer-Reviewed Publications 08 Jun 2020 English

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study, mAbs

A comprehensive case study comparing conventional batch and intensified continuous biomanufacturing demonstrates significant productivity and cost benefits.

Multi-Dimensional Chromatography (2D/3D) Contichrom® CUBE mAbs & Antibody Variants

Peer-Reviewed Publications 05 Feb 2020 English

Process-wide control and automation of an integrated continuous manufacturing platform for antibodies, Biotechnol. Bioeng.

Automated end-to-end integrated continuous manufacturing combines perfusion bioreactor, CaptureSMB, virus inactivation, and polish chromatography.

Continuous Capture (CaptureSMB®) Dynamic Process Control (AutoPeak® & AutomAb®) Multi-Dimensional Chromatography (2D/3D) Contichrom® CUBE mAbs & Antibody Variants

Peer-Reviewed Publications 04 Jan 2018 English

Continuous integrated manufacturing of therapeutic proteins, Curr. Opin. Biotechnol.

Review of continuous integrated manufacturing concepts for therapeutic proteins discussing upstream-downstream integration and process control strategies.

Continuous Capture (CaptureSMB®) Multi-Dimensional Chromatography (2D/3D) mAbs & Antibody Variants Antibody-drug Conjugates Recombinant Proteins

Educational Articles

Fundamentals of Preparative Chromatography 25 Nov 2025

Part I – What Is Chromatography? The Universal Primer for New Scientists

A practical primer on chromatography: what it is, how it works, and why it matters. Learn about key separation mechanisms including reversed-phase, ion exchange, size exclusion and affinity chromatography, plus how to read chromatograms and the difference between analytical and preparative methods.

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