Brochures & Datasheets
04 Dec 2025
RESOURCE LIBRARY
Continuous Chromatography Resources — Application Notes, Webinars & Papers
The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.
Recent MCSGP Research Highlights
The first peer-reviewed PC/PPQ framework for MCSGP
The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.
Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)
First peer-reviewed AIEX MCSGP for therapeutic siRNA
First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.
Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)
Proof-of-concept MCSGP for AAV2 polishing
Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.
Müller et al.
Biotechnol. Bioeng. (Open-Access)
Resource Library
Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.
- All Media Types
- Application Notes
- Webinars & Videos
- Process Guides & Manuals
- Peer-Reviewed Publications
- Brochures & Datasheets
- White Papers
Application Notes
03 Dec 2025
Highly pure Cannabidiol (CBD) by twin-column chromatography (MCSGP)
This application note shows how highly pure CBD with a THC content below 100 ppm was obtained from pre-treated hemp plant extract. The process provided a yield of 95%, an increase of 72% relative to single column batch chromatography.
Application Notes
03 Dec 2025
Purification of ADCs using Continuous Chromatography (MCSGP)
MCSGP was used for the purification of Antibody Drug Conjugates (ADCs) with various Drug-Antibody-Ratios (DARs) for a non-specifically conjugated model system, representing the Antibody-Drug-Conjugate Trastuzumab Emtansine (Kadcyla®).
Brochures & Datasheets
03 Dec 2025
Contichrom PILOT 300X Brochure
Overview of the technical specifications and functionalities offered by the Contichrom PILOT 300X
Peer-Reviewed Publications
16 Jul 2025
UV-based dynamic control improves the robustness of multicolumn countercurrent solvent gradient purification of oligonucleotides, Biotechnol. J.
AutoPeak, a UV-based dynamic process controller, automatically adjusts recycling and collection windows in MCSGP to maintain product quality during extended continuous operations.
Peer-Reviewed Publications
07 Jul 2025
Separation of Empty and Full Adeno-Associated Viral Capsids by MCSGP: From Model-Based Design to Implementation, J. Chromatogr. A
Model-based optimization of anion exchange separation of empty and full AAVs demonstrates that MCSGP increases full recovery 5-fold and productivity 2.5-fold while reducing process mass intensity to one-third compared to batch.
Educational Articles
Fundamentals of Preparative Chromatography
13 May 2026
Modern Chromatography: A Comprehensive Introduction
A practical primer on chromatography: what it is, how it works, and why it matters. Learn about key separation mechanisms including reversed-phase, ion exchange, size exclusion and affinity chromatography, plus how to read chromatograms and the difference between analytical and preparative methods.
Fundamentals of Preparative Chromatography
13 May 2026
What Is Preparative Chromatography? Analytical vs. Preparative, Explained
Analytical chromatography produces data; preparative chromatography produces purified material. This guide explains the key differences in goals, scale, column design and optimization strategies, and why every preparative step is a balance of competing goals—purity, yield and throughput.
YMC ChromaCon Chromatography Newsletter.
Subscribe for New Resources Unsubscribe anytime.