Brochures & Datasheets
04 Dec 2025
RESOURCE LIBRARY
Continuous Chromatography Resources — Application Notes, Webinars & Papers
The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.
Recent MCSGP Research Highlights
The first peer-reviewed PC/PPQ framework for MCSGP
The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.
Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)
First peer-reviewed AIEX MCSGP for therapeutic siRNA
First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.
Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)
Proof-of-concept MCSGP for AAV2 polishing
Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.
Müller et al.
Biotechnol. Bioeng. (Open-Access)
Resource Library
Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.
- All Media Types
- Application Notes
- Webinars & Videos
- Process Guides & Manuals
- Peer-Reviewed Publications
- Brochures & Datasheets
- White Papers
Brochures & Datasheets
03 Dec 2025
Contichrom PILOT 300X Brochure
Overview of the technical specifications and functionalities offered by the Contichrom PILOT 300X
White Papers
16 Oct 2024
Reducing Solvent Consumption for Large-Scale Peptide API Manufacturing
Bachem white paper about “Reducing Solvent Consumption for Large-Scale Peptide API Manufacturing” using MCSGP
Peer-Reviewed Publications
16 Feb 2022
Enrichment and purification of peptide impurities using twin-column continuous chromatography, J. Chromatogr. A
N-Rich demonstrated for peptide impurity isolation with up to 15-fold purity improvements and 20-fold mass enrichment compared to conventional methods.
Webinars & Videos
06 Jul 2021
Continuous Chromatography of Peptides
Bachem webinar about the “Continuous Chromatography of Peptides” using MCSGP
Peer-Reviewed Publications
03 May 2021
Process Intensification for the Purification of Peptidomimetics: The Case of Icatibant through MCSGP, Ind. Eng. Chem. Res.
MCSGP applied for Icatibant peptidomimetic purification demonstrates significant yield improvements and establishes economic viability across manufacturing scenarios.
Educational Articles
Oligo Purification
07 Sep 2026
Reversed-Phase MCSGP for GalNAc-Conjugated Oligonucleotides
Purification is where oligonucleotide yield is lost, and the synthesis has to be sized to cover it. Converting a reversed-phase batch method for a GalNAc-conjugated gapmer to twin-column MCSGP lifted recovery from 52.7% to 91.6% at the same purity — enough to shrink the synthesis step by 42.5% for the same daily output.
Oligo Purification
27 Aug 2026
Continuous Anion Exchange Purification of a Conjugated siRNA
An established anion exchange batch method for a conjugated siRNA sense strand, converted to continuous twin-column MCSGP: 13 cycles, 27 product elutions, and yield up from 80% to 93% at unchanged purity — plus a software-aided route from batch chromatogram to running method.
Peptide Purification
26 Aug 2026
MCSGP Process Validation: Characterization and PPQ at Commercial Scale
Continuous chromatography is already in production use, but there was no published account of how to validate it for a regulatory filing. This study provides one, working through Process Characterization and Performance Qualification for MCSGP on commercial-scale Bivalirudin purification: 34 parameters assessed, four tested, one critical.
Peptide Purification
25 Aug 2026
Acetonitrile- and TFA-Free Peptide Purification with MCSGP
Green solvents have always cost the peptide industry recovery. This study shows the loss is a property of batch chromatography, not of the solvent: run the same green eluent counter-currently and the yield comes back.
YMC ChromaCon Chromatography Newsletter.
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