Brochures & Datasheets
04 Dec 2025
RESOURCE LIBRARY
Continuous Chromatography Resources — Application Notes, Webinars & Papers
The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.
Recent MCSGP Research Highlights
The first peer-reviewed PC/PPQ framework for MCSGP
The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.
Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)
First peer-reviewed AIEX MCSGP for therapeutic siRNA
First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.
Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)
Proof-of-concept MCSGP for AAV2 polishing
Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.
Müller et al.
Biotechnol. Bioeng. (Open-Access)
Resource Library
Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.
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Brochures & Datasheets
03 Dec 2025
Contichrom PILOT 300X Brochure
Overview of the technical specifications and functionalities offered by the Contichrom PILOT 300X
Peer-Reviewed Publications
16 Jul 2025
UV-based dynamic control improves the robustness of multicolumn countercurrent solvent gradient purification of oligonucleotides, Biotechnol. J.
AutoPeak, a UV-based dynamic process controller, automatically adjusts recycling and collection windows in MCSGP to maintain product quality during extended continuous operations.
Peer-Reviewed Publications
02 Jun 2025
Continuous Purification of a Conjugated Short Interfering RNA Therapeutic Using Anion Exchange Twin-Column Chromatography (MCSGP), Org. Process Res. Dev.
An MCSGP process is developed for purification of a sugar-conjugated siRNA therapeutic using anion exchange chromatography, demonstrating yield improvements from 80% to 93% compared to single-column chromatography.
Peer-Reviewed Publications
16 Dec 2024
Overview and Recent Advances in the Purification and Isolation of Therapeutic Oligonucleotides, Org. Process Res. Dev.
A comprehensive review of traditional and emerging purification technologies for therapeutic oligonucleotides, highlighting MCSGP as a promising approach to overcome yield-purity tradeoffs.
Peer-Reviewed Publications
15 Oct 2024
Integrated multidimensional chromatography on preparative scale for oligonucleotides purification, J. Chromatogr. A
Integrated multidimensional chromatography combining different separation modes enables comprehensive oligonucleotide purification at preparative scale.
Educational Articles
Fundamentals of Preparative Chromatography
13 May 2026
Modern Chromatography: A Comprehensive Introduction
A practical primer on chromatography: what it is, how it works, and why it matters. Learn about key separation mechanisms including reversed-phase, ion exchange, size exclusion and affinity chromatography, plus how to read chromatograms and the difference between analytical and preparative methods.
Fundamentals of Preparative Chromatography
13 May 2026
What Is Preparative Chromatography? Analytical vs. Preparative, Explained
Analytical chromatography produces data; preparative chromatography produces purified material. This guide explains the key differences in goals, scale, column design and optimization strategies, and why every preparative step is a balance of competing goals—purity, yield and throughput.
YMC ChromaCon Chromatography Newsletter.
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