RESOURCE LIBRARY
The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.
The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.
Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)
First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.
Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)
Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.
Müller et al.
Biotechnol. Bioeng. (Open-Access)
Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.
Twin-column cation-exchange MCSGP for biomolecule purification showcases yield and productivity improvements over batch processing.
MCSGP applied for therapeutic peptide purification demonstrates simultaneous achievement of high purity and yield targets unattainable with batch chromatography.
MCSGP applied for purification of common light-chain bispecific antibodies addresses the unique separation challenges posed by this antibody format.
Online control strategies for twin-column MCSGP processes enable real-time process monitoring and automated optimization.
MCSGP applied for continuous separation of lanthanide elements demonstrates the technology’s versatility beyond biopharmaceutical applications.
Extension of MCSGP to multifraction separations demonstrates purification of multiple intermediate-eluting species in a single continuous operation.
A practical primer on chromatography: what it is, how it works, and why it matters. Learn about key separation mechanisms including reversed-phase, ion exchange, size exclusion and affinity chromatography, plus how to read chromatograms and the difference between analytical and preparative methods.
Analytical chromatography produces data; preparative chromatography produces purified material. This guide explains the key differences in goals, scale, column design and optimization strategies, and why every preparative step is a balance of competing goals—purity, yield and throughput.
YMC ChromaCon Chromatography Newsletter.
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