Brochures & Datasheets
04 Dec 2025
RESOURCE LIBRARY
Continuous Chromatography Resources — Application Notes, Webinars & Papers
The evidence behind every Contichrom® process. Download the open-access PPQ paper, browse application notes by molecule, watch on-demand webinars, and access the peer-reviewed publications underpinning MCSGP, CaptureSMB®, and N-Rich® at GMP commercial scale.
Recent MCSGP Research Highlights
The first peer-reviewed PC/PPQ framework for MCSGP
The first peer-reviewed PC/PPQ framework for MCSGP. 95% IPC reduction, 73% PMI reduction, 96% gross-to-gross yield — validated at GMP commercial scale on Bachem Bivalirudin.
Eisenhuth, R. & Müller-Späth, T. — Processes, 2025 (Open-Access)
First peer-reviewed AIEX MCSGP for therapeutic siRNA
First peer-reviewed AIEX MCSGP for therapeutic siRNA. Yield improved from 80% to 93% on a sugar-conjugated siRNA sense strand — software-aided method development enabled fast batch-to-MCSGP transfer. Throughput increased 87%.
Weldon et al. Org. Process Res. Dev. 2025, (Open-Access)
Proof-of-concept MCSGP for AAV2 polishing
Proof-of-concept MCSGP for AAV2 polishing. Full capsid content increased from 30% to 68% (ddPCR) after six cycles — with +20.6% yield, +23% productivity, and 27% reduced buffer consumption vs batch AEX. AutoPeak® PAT validated against cryo-TEM and ddPCR.
Müller et al.
Biotechnol. Bioeng. (Open-Access)
Resource Library
Application notes, peer-reviewed papers, process guides, datasheets, and recorded webinars — searchable by application, technology, product, or service.
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Peer-Reviewed Publications
15 Dec 2022
Obtaining acidic and basic charge variants using a twin-column continuous chromatography system, Protein Expr. Purif.
A twin-column continuous chromatography method enables simultaneous separation and collection of both acidic and basic mAb charge variants in a single continuous operation.
Peer-Reviewed Publications
15 Oct 2022
Enrichment and recovery of oligonucleotide impurities by N-Rich twin-column continuous chromatography, J. Chromatogr. B
N-Rich applied for simultaneous isolation of multiple low-concentration dsRNA impurities enables efficient characterization of oligonucleotide process-related substances.
Peer-Reviewed Publications
16 Feb 2022
Enrichment and purification of peptide impurities using twin-column continuous chromatography, J. Chromatogr. A
N-Rich demonstrated for peptide impurity isolation with up to 15-fold purity improvements and 20-fold mass enrichment compared to conventional methods.
Peer-Reviewed Publications
18 Mar 2021
Using continuous chromatography methodology to achieve high-productivity and high-purity enrichment of charge variants for analytical characterization, J. Chromatogr. A
N-Rich continuous chromatography for mAb charge variant enrichment achieves 95% purity in 10 hours versus 78-87% purity in 48-300 hours with conventional methods.
Peer-Reviewed Publications
28 Jan 2021
A novel twin-column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants, Eng. Life Sci.
N-Rich applied for mAb acidic variant enrichment achieves 86% yield at nearly 100% purity compared to 59% yield with scaled-up batch chromatography.
Educational Articles
Fundamentals of Preparative Chromatography
13 May 2026
Modern Chromatography: A Comprehensive Introduction
A practical primer on chromatography: what it is, how it works, and why it matters. Learn about key separation mechanisms including reversed-phase, ion exchange, size exclusion and affinity chromatography, plus how to read chromatograms and the difference between analytical and preparative methods.
Fundamentals of Preparative Chromatography
13 May 2026
What Is Preparative Chromatography? Analytical vs. Preparative, Explained
Analytical chromatography produces data; preparative chromatography produces purified material. This guide explains the key differences in goals, scale, column design and optimization strategies, and why every preparative step is a balance of competing goals—purity, yield and throughput.
YMC ChromaCon Chromatography Newsletter.
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