Zurich, Switzerland – February 2016 – ChromaCon AG, announces the worldwide launch of the Contichrom® CUBE 100 FPLC system.
The Contichrom® CUBE 100 extends the proven Contichrom® CUBE 30 platform with a nearly three-fold higher maximum flow rate of 100 mL/min, allowing users to process larger feed volumes while maintaining robust performance and user-friendly operation.
Dedicated FPLC System for Intermediate-Scale Process Development
The Contichrom® CUBE 100 FPLC system is a dedicated chromatography workstation for laboratories that need to bridge the gap between small-scale discovery and GMP-scale manufacturing. It supports a wide range of protein and oligonucleotide purification workflows and is especially suited for intermediate-scale process development of batch, cyclic, and continuous chromatography processes.
With its increased flow rate, the CUBE 100 helps process development teams work more efficiently when screening conditions, optimizing methods, and preparing larger quantities of material for downstream studies and scale-up.
Built on the Proven Contichrom® CUBE Platform
The CUBE 100 is a direct product extension of the Contichrom® CUBE 30 systems launched in early 2015. It employs the same intuitive ChromIQ® software, giving users a unified interface across the CUBE platform and simplifying technology transfer between systems.
- Higher capacity – Maximum flow rate of 100 mL/min, nearly three times higher than the CUBE 30, enabling larger feed volumes and faster method execution.
- Consistent software environment – Uses the same ChromIQ® control software and process library as the Contichrom® CUBE 30, ensuring a smooth learning curve and easy method transfer.
- Flexible chromatography modes – Supports batch, cyclic, and continuous chromatography processes, allowing users to evaluate and implement advanced purification strategies.
- Optimized for proteins and oligonucleotides – Designed for high-throughput protein purification and oligonucleotide purification applications in R&D and process development labs.
Enabling Scale-Up to GMP Twin-Column Systems
The Contichrom® CUBE 100 is particularly valuable for the development of continuous chromatography processes that are later scaled up to GMP production. Methods established on the CUBE 100 can be transferred to twin-column chromatography systems manufactured by ChromaCon’s partner LEWA Process Technologies (Devens, MA, USA).
This alignment between laboratory-scale equipment and industrial-scale systems helps shorten development timelines and supports a smoother transition from process development to clinical and commercial manufacturing.
About ChromaCon
ChromaCon AG is a private life science tools company located in Zürich, Switzerland, providing best-in-class process solutions to the biopharmaceutical industry. The company has developed and patented novel process principles, process control strategies, equipment designs, and operating software for batch, cyclic, and continuous chromatography, enabling significant CAPEX and OPEX savings and scalable solutions for large-scale purification applications.
The Contichrom® laboratory-scale equipment is co-marketed worldwide by ChromaCon and its partners. ChromaCon has granted global licenses for its process technologies to LEWA Process Technologies for implementation into scale-up systems. In addition, ChromaCon develops and markets affinity purification solutions for column and membrane chromatography, as well as tools for site-specific protein conjugation.
Contact ChromaCon
For more information about the Contichrom® CUBE 100 FPLC system and ChromaCon’s chromatography solutions, please contact:
ChromaCon AG
Dr Thomas Müller-Späth
Email:
Website: www.chromacon.com
