3-Day Continuous Chromatography Workshop for mAbs, Oligonucleotides and Peptides, 8th - 10th September 2026 Learn More

CONTINUOUS CHROMATOGRAPHY

More Product. Fewer IPCs. MCSGP for Peptide & Oligo Manufacturing

MCSGP + AutoPeak®: a twin-column preparative chromatography process with UV-based dynamic process control. Eliminates the purity–yield trade-off in preparative HPLC for reversed-phase and AIEX polishing of peptides and oligonucleotides. AutoPeak® — essential for MCSGP manufacturing — available only on the Contichrom® platform

Across 4 PPQ runs: 99.2% Purity | −96% In-process controls | −73% Process Mass Intensity | Multi-day unattended operation | +9% Yield gain

Source: Eisenhuth & Müller-Späth, Processes 2025 (Bachem Bivalirudin PPQ campaign, Open Access)

Discuss Your Process
Download the PPQ Paper
Scientist operating a Contichrom CUBE continuous chromatography system for MCSGP peptide and oligonucleotide polishing
Discuss Your Process
Download the PPQ Paper

Find the Ideal Twin-Column Process for Your Application

Whether you need MCSGP continuous polishing for peptides and oligonucleotides or CaptureSMB® continuous capture for mAbs and biologics, YMC ChromaCon’s Contichrom® systems deliver higher yield, lower cost, and consistent results from lab to production scale.

Peptides
Peptides

MCSGP with AutoPeak® achieves scalable, cost-effective purification for complex synthetic peptides, maximizing recovery by automatically recycling low purity side-cuts.
Oligonucleotides
Oligonucleotides

MCSGP with AutoPeak® breaks the yield-purity tradeoff delivering higher oligonucleotide yields without sacrificing purity.

mAbs & Antibody Variants
mAbs & Antibody Variants

CaptureSMB® with AutomAb® for mAbs & antibody variants: maximize productivity and resin utilization, while slashing buffer consumption.
Antibody-drug Conjugates
Antibody-drug Conjugates

MCSGP with AutoPeak® is ideally suited for DAR control, achieving precise drug-antibody ratios with higher yield than batch chromatography.
Recombinant Proteins
Recombinant Proteins

From capture through polishing, Contichrom® integrates multiple chromatography steps into automated 2D/3D workflows — reducing hands-on time and intermediate handling.
Viral Vectors (AAV)
Viral Vectors (AAV)

Continuous chromatography improves full/empty capsid separation and recovery, supporting scalable AAV manufacturing.
Small Molecules & Nutraceuticals
Small Molecules & Nutraceuticals

High-pressure continuous chromatography on the Contichrom® platform enables efficient purification of natural compounds and small molecules at preparative scale.

Impurity Isolation
Impurity Isolation

N-Rich automates on-column enrichment of low-abundance impurities, replacing weeks of repetitive HPLC runs with a single automated process.
Technologies Overview

Maximize Efficiency with Twin-Column Technology

Multi-Dimensional Chromatography (2D/3D)

Automate sequential purification across multiple columns and chemistries in a single run. ChromIQ® handles fraction transfer, timing, and method switching.

Continuous Polishing (MCSGP)

Overlapping fractions are automatically recycled between twin columns, breaking the yield–purity tradeoff. AutoPeak® dynamic control maintains performance cycle to cycle.

Continuous Capture (CaptureSMB®)

Twin-column continuous loading maximizes resin utilization and throughput. AutomAb® dynamically controls breakthrough — adapting in real time to feed variability.

Continuous Enrichment (N-Rich®)

Automated on-column enrichment of trace-level impurities from repeated injections. Replaces weeks of manual fraction pooling with a single unattended run.

Dynamic Process Control (AutoPeak® & AutomAb®)

Real-time UV-based control that adapts your continuous process to feed and column variability — eliminating the need for fixed, conservative operating parameters.

Scalable Purification Solutions from Lab to GMP

Seamlessly transfer your Contichrom® process from benchtop to production. Our integrated platform simplifies complex purifications to maximize yield, purity, and efficiency at every scale—from R&D to commercial manufacturing.

Contichrom® CUBE

The essential platform for chromatography process development. This versatile 100-bar benchtop FPLC system runs batch, integrated batch, and continuous chromatography — including MCSGP and CaptureSMB — out of the box. Develop purification processes for mAbs, peptides, oligonucleotides, ADCs, and viral vectors, with verified scale-up at over 100× to pilot and production systems.

Contichrom® PILOT

Scale peptide and oligonucleotide purification to pilot and clinical GMP manufacturing. This 100-bar preparative HPLC system features MCSGP with AutoPeak® to eliminate the yield-purity trade-off — delivering +10–50% absolute yield increase at target purity and significantly less solvent than batch HPLC. ATEX Zone 2 / Class I Div 2 certified for organic solvents. Flow rates up to 300 mL/min.

Contichrom® TWIN HPLC

Produce peptides and oligonucleotides at commercial GMP scale. This 80-bar industrial HPLC system uses MCSGP with AutoPeak® to eliminate the yield-purity trade-off — increasing recovery to >90% while reducing solvent consumption compared to batch. ATEX Zone 2 / Class I Div 2 certified for organic solvents, and flow rates up to 36 L/min.

Contichrom® TWIN LPLC – Capture

Accelerate biopharmaceutical capture chromatography at production scale. This sanitary GMP system uses CaptureSMB® with AutomAb® to maximize resin utilization — achieving up to 3× faster processing and 50% less Protein A resin and buffer consumption compared to batch. CIP-ready design for mAbs, viral vectors, ADCs, and recombinant proteins.

Contichrom® TWIN LPLC – Polishing

Bring continuous polishing to biopharmaceutical manufacturing at production scale. This sanitary GMP system uses MCSGP with AutoPeak® to eliminate the yield-purity trade-off achieving +10–50% absolute yield increase at target purity while reducing buffer consumption compared to batch. CIP-ready design for mAbs, viral vectors, ADCs, and recombinant proteins.

Systems Overview

Explore our  Service Offerings

From first introduction to Contichrom® technologies to scale-up and validation, our service offerings support you at every step of your purification journey.

Demos & Introductions
Demos & Introductions

See Contichrom® in action. On-site, at our facility, or remote — get a first-hand look at what our chromatography systems and software can do.
Training & Consulting
Training & Consulting

Hands-on operator training, advanced application workshops, and expert consulting — customised to your team’s experience and your specific Contichrom® applications.
Process Modeling
Process Modeling

Calibrated mechanistic models built from your batch data — simulate and optimize batch, MCSGP, or CaptureSMB® processes computationally, before running a single experiment.
System Rentals
System Rentals

Try a Contichrom® system in your own lab before committing to a purchase. Full technical support and training included — evaluate the technology on your terms.
Feasibility Studies
Feasibility Studies

Quantified performance comparison. Run your molecule on our Contichrom® systems and benchmark CaptureSMB® or MCSGP against your existing batch process.

Custom Purification
Custom Purification

Need purified material, but not equipment? We develop and run the separation for you — delivering formulated fractions from your starting material using Contichrom® technology.
Maintenance & Repair
Maintenance & Repair

Preventive maintenance subscriptions and on-site repair services to keep your Contichrom® running at peak performance. Remote technical support available worldwide.

News & Events

2026 – Continuous Chromatography Workshop for mAbs, Oligonucleotides and Peptides
News & Events 08 Sep 2026

2026 – Continuous Chromatography Workshop for mAbs, Oligonucleotides and Peptides

From 8–10 September 2026, the Institute for Pharma Technology at FHNW hosts a 3-day seminar at the Muttenz (Basel) campus in Switzerland. Combining lectures, case studies and hands-on twin-column training, participants gain practical skills in continuous chromatography for mAbs, oligonucleotides, peptides and viral vectors.

“The era of large-scale peptide & oligo purification with MCSGP has begun”
News & Events 01 Feb 2024

“The era of large-scale peptide & oligo purification with MCSGP has begun”

Bachem has successfully transitioned to large-scale, GMP-compliant purification of peptides and oligonucleotides using MCSGP continuous chromatography. This milestone confirms MCSGP as a proven production technology for the global TIDES market, with capacity for up to two tons of crude peptides per line.

FDA Selects YMC Twin-Column Continuous Chromatography System for Evaluation
News & Events 16 Jul 2020

FDA Selects YMC Twin-Column Continuous Chromatography System for Evaluation

The U.S. FDA has selected the YMC Contichrom® CUBE twin-column continuous chromatography system to evaluate advanced purification strategies for biopharmaceutical manufacturing. This acquisition signals growing regulatory interest in continuous chromatography to reduce costs and increase productivity.

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Why Leading Innovators Choose YMC ChromaCon

With decades of chromatography expertise and proprietary twin-column technologies, YMC ChromaCon helps biopharma teams purify smarter, scale faster, and reduce cost—without compromising quality.

Trusted by Bachem, Novartis, and Leading CDMOs

Proprietary MCSGP, CaptureSMB & AutoPeak® Technology

Expert Process Development, Scale-Up & Training

Success Stories

“The IPC samples are dramatically lower with this technology (MCSGP) and Manufacturing really likes this.”
(Presentation: Development and Manufacture of Oligonucleotides via Enzymatic Ligation
25 Feb 2026, TIDES Asia, Tokyo)

Dr. Scott May VP Chemistry – Genetic Medicines CMC, Eli Lilly and Company

“For oligonucleotides, MCSGP will be a game changer due to Increased sustainability of the purification processes and reduction of cost of goods due to higher yields, automation and lower solvent consumption.“

Ralf Eisenhuth Principal Process Manager Chromatography, Bachem AG

“Very high recovery was possible using MCSGP, and productivity exceeded the reference process by 3x ”

Roman Hillebrand Associate Director, Manufacturing Innovation, Arrowhead

“MCSGP Performance indicators highlight positive impact for scale-up manufacturing, possibly including a 20-50% reduction in eluent use” (Presentation: TIDES Europe, 13th Nov 2025)

Bertrand Guelat Senior Expert Science & Technology, Novartis

Ready to Upgrade Your Purification Process?

Request a Webinar Register for the Continuous Chromatography Workshop