Dr. Thomas Müller-Späth

Scientific Roots & The Birth of MCSGP:

Thomas holds a PhD in Chemical Engineering from the Swiss Federal Institute of Technology (ETH Zurich), where he conducted his doctoral research in the renowned Morbidelli Group. It was here that he helped pioneer Multi-column Counter-current Solvent Gradient Purification (MCSGP)—a technology now regarded as a benchmark for solving difficult purification trade-offs.

Education:

PhD, ETH Zurich; Dipl.-Ing., Technical University of Hamburg; Exchange Student, University of California, Berkeley.

Research Focus:

Continuous chromatography, process modeling, and the purification of complex biomolecules.

From Concept to Industrial Standard:

Co-founding ChromaCon in 2006, Thomas was instrumental in translating complex academic concepts into the robust Contichrom® hardware platform. He has guided the technology from bench-top curiosity to a GMP-ready manufacturing solution used by leading pharma companies worldwide. His work has been critical in proving that continuous processes (such as CaptureSMB for mAbs and MCSGP for peptides/oligonucleotides) can significantly reduce CAPEX/OPEX while improving product quality.

Thought Leadership:

Thomas remains an active contributor to the scientific community. He is an inventor on multiple core patents in continuous processing and has authored over 30 scientific publications. He is a frequent speaker at major industry conferences (TIDES, SPICA, PREP), where he advocates for the economic and technical benefits of continuous downstream processing.