TECHNOLOGIES

Contichrom® – Continuous Chromatography Technologies

Five process modes, one hardware platform. Run batch, integrated 2D/3D batch, or fully continuous chromatography (MCSGP, CaptureSMB®, N-Rich®) on the same Contichrom® system — with the same resins, the same buffers, and a single ChromIQ® software environment.

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Advanced Chromatography for Every Purification Challenge

One platform, five process modes. The Contichrom® system runs batch, multi-dimensional (2D/3D), and twin-column continuous chromatography — so you can match the right technology to every molecule and every stage of development.

Higher yield, lower cost. Continuous processes like MCSGP resolve the purity-yield trade-off, reduce solvent and buffer consumption, and enable 24/7 automated manufacturing — significantly lowering cost of goods.

Select a technology below to learn how it works, see application data, and find the right Contichrom® system for your process.

Choose a Technology

Five process modes, one hardware platform.

Batch Chromatography
Batch Chromatography

Single-column purification with full method flexibility — gradient, isocratic, step elution. The foundation for process development and the starting point for continuous workflows.
Multi-Dimensional Chromatography (2D/3D)
Multi-Dimensional Chromatography (2D/3D)

Automate sequential purification across multiple columns and chemistries in a single run. ChromIQ® handles fraction transfer, timing, and method switching.
Continuous Capture (CaptureSMB®)
Continuous Capture (CaptureSMB®)

Twin-column continuous loading maximizes resin utilization and throughput. AutomAb® dynamically controls breakthrough — adapting in real time to feed variability.
Continuous Polishing (MCSGP)
Continuous Polishing (MCSGP)

Overlapping fractions are automatically recycled between twin columns, breaking the yield–purity tradeoff. AutoPeak® dynamic control maintains performance cycle to cycle.
Continuous Enrichment (N-Rich®)
Continuous Enrichment (N-Rich®)

Automated on-column enrichment of trace-level impurities from repeated injections. Replaces weeks of manual fraction pooling with a single unattended run.
Dynamic Process Control (AutoPeak® & AutomAb®)
Dynamic Process Control (AutoPeak® & AutomAb®)

Real-time UV-based control that adapts your continuous process to feed and column variability — eliminating the need for fixed, conservative operating parameters.

Frequently Asked Questions