Preparative Chromatography Systems from Bench to Batch Release

Both systems share identical process capabilities — batch, 2D/3D, MCSGP, CaptureSMB, and N-Rich. The CUBE 30 is optimized for smaller columns (up to 2.7 cm ID) at flow rates up to 36 mL/min, while the CUBE 100 supports columns up to 5.0 cm ID at flow rates up to 100 mL/min. Choose based on your typical column diameter and throughput needs.

Yes. The Contichrom platform is designed for direct method transfer. Processes developed on the CUBE scale predictably to the PILOT 300X and TWIN systems. The ChromIQ® software ecosystem ensures consistent method parameters across all system scales.

The TWIN HPLC operates at up to 80 bar and is designed for high-pressure applications such as reversed-phase chromatography of peptides and oligonucleotides. The TWIN LPLC operates at lower pressures (≤20 bar) and is designed for large-molecule biologics processes including Protein A capture and ion exchange polishing. Both share the same industrial automation platform.

Yes. The PILOT 300X and TWIN HPLC are certified for ATEX Zone 2 / Class I Division 2 hazardous environments, making them fully suitable for use with organic solvents such as acetonitrile and methanol in reversed-phase chromatography.

The platform supports a wide range of biopharmaceuticals: peptides (including GLP-1 agonists), oligonucleotides, monoclonal antibodies, antibody-drug conjugates, recombinant proteins, viral vectors (AAV), mRNA, vaccines, and blood plasma proteins. Column chemistries include RP (C18, C8, C4), IEX, Protein A/L/G, HIC, MMC, IMAC, and SEC.

The CUBE systems run ChromIQ® 9, a wizard-driven software suite for method development across all process modes. The PILOT 300X runs ChromIQ® X, designed for GMP-regulated environments with 21 CFR Part 11 compliance. The TWIN production systems use a Rockwell Automation-based platform with integrated MCSGP/AutoPeak® control.