{"id":16884,"date":"2025-11-25T10:27:11","date_gmt":"2025-11-25T09:27:11","guid":{"rendered":"https:\/\/www.chromacon.com\/articles-educatifs\/"},"modified":"2026-09-01T11:16:22","modified_gmt":"2026-09-01T09:16:22","slug":"articles-educatifs","status":"publish","type":"page","link":"https:\/\/www.chromacon.com\/fr\/articles-educatifs\/","title":{"rendered":"Articles \u00e9ducatifs"},"content":{"rendered":"<section id=\"block_e8a4e80d652973eaadc16536a1fc9ca6\" class=\"block-news-archive py-fluid-2xl md:pt-fluid-6xl md:pb-fluid-8xl alignfull  \"><div class=\"l-wrap\">    \n    <div class=\"news-archive-wrapper\" data-posts-per-page=\"20\" data-post-type=\"articles\">\n                            <div class=\"news-archive-header max-w-[860px] mb-fluid-4xl\">\n                                    <h1 class=\"text-display-m leading-display-m text-primary-800 pb-fluid-m [&#038;_strong]:text-secondary-700 [&#038;_strong]:font-medium typo-off\">\n                        Chromatographie continue \u2013 Articles &#038; analyses\n                    <\/h1>\n                                                    <p class=\"!m-0\">\n                        Explorez nos ressources, guides et analyses sur les technologies de purification et les innovations de l&#039;industrie.                    <\/p>\n                            <\/div>\n                \n                <nav class=\"news-archive-categories mb-fluid-2xl\" role=\"navigation\" aria-label=\"Category navigation\">\n            <ul class=\"flex gap-4 md:gap-[75px] overflow-x-auto whitespace-nowrap\">\n                                    <li>\n                        <a \n                            href=\"https:\/\/www.chromacon.com\/fr\/articles-educatifs\/\" \n                            class=\"block pb-4 text-18 md:text-20 text-gray-600 hover:text-gray-900 transition-colors relative text-gray-900 font-medium\"\n                            data-category-slug=\"\"\n                        >\n                            Tout                                                            <span class=\"absolute bottom-0 left-0 right-0 h-0.5 bg-primary-800\"><\/span>\n                                                    <\/a>\n                    <\/li>\n                                    <li>\n                        <a \n                            href=\"https:\/\/www.chromacon.com\/fr\/articles-educatifs\/?category=fondamentaux-de-la-chromatographie-preparative\" \n                            class=\"block pb-4 text-18 md:text-20 text-gray-600 hover:text-gray-900 transition-colors relative \"\n                            data-category-slug=\"fondamentaux-de-la-chromatographie-preparative\"\n                        >\n                            Fondamentaux de la chromatographie pr\u00e9parative                                                    <\/a>\n                    <\/li>\n                                    <li>\n                        <a \n                            href=\"https:\/\/www.chromacon.com\/fr\/articles-educatifs\/?category=troubleshooting-best-practices\" \n                            class=\"block pb-4 text-18 md:text-20 text-gray-600 hover:text-gray-900 transition-colors relative \"\n                            data-category-slug=\"troubleshooting-best-practices\"\n                        >\n                            Troubleshooting &amp; Best Practices                                                    <\/a>\n                    <\/li>\n                            <\/ul>\n        <\/nav>\n        \n                            <div class=\"news-archive-grid grid grid-cols-1 md:grid-cols-2 lg:grid-cols-3 gap-x-fluid-s-plus gap-y-fluid-4xl-plus\">\n                                    <article class=\"news-card overflow-hidden\">\n            \n                            <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/mcsgp-en-phase-inverse-pour-les-oligonucleotides-conjugues-au-galnac\/\" class=\"block relative w-full aspect-[4\/3] overflow-hidden mb-fluid-s-plus\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2025\/12\/Generated-Image-April-29-2026-12_49AM-768x768.jpg\"\n                    alt=\"MCSGP en phase inverse pour les oligonucl\u00e9otides conjugu\u00e9s au GalNAc\"\n                    class=\"w-full h-full object-cover !m-0\"\n                    loading=\"lazy\" \/>\n            <\/a>\n        \n                <div class=\"flex gap-3 items-center mb-fluid-xs\">\n                            <span class=\"px-fluid-3xs py-2.5 bg-[#EEF5FE] text-secondary-700 text-s rounded-full\">\n                    Purification d\u2019oligo                <\/span>\n                        <span class=\"text-secondary-700 text-s border border-gray-50 rounded-full px-fluid-3xs py-2.5\">\n                07 Sep 2026            <\/span>\n        <\/div>\n\n                <div class=\"\">\n                            <h3 class=\"heading-h4 !m-0 pb-fluid-xs typo-off\">\n                    <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/mcsgp-en-phase-inverse-pour-les-oligonucleotides-conjugues-au-galnac\/\" class=\"!no-underline\">\n                        MCSGP en phase inverse pour les oligonucl\u00e9otides conjugu\u00e9s au GalNAc                    <\/a>\n                <\/h3>\n            \n                            <p class=\"!mb-0\">\n                    La purification est l\u2019\u00e9tape o\u00f9 le rendement en oligonucl\u00e9otides est perdu, et la synth\u00e8se doit \u00eatre dimensionn\u00e9e en cons\u00e9quence. La conversion d&#039;une m\u00e9thode par lots en phase inverse pour un gapmer conjugu\u00e9 au GalNAc en MCSGP \u00e0 deux colonnes a augment\u00e9 la r\u00e9cup\u00e9ration de 52,7 % \u00e0 91,6 % avec la m\u00eame puret\u00e9 \u2014 suffisamment pour r\u00e9duire l&#039;\u00e9tape de synth\u00e8se de 42,5 % pour la m\u00eame production quotidienne.                 <\/p>\n                    <\/div>\n\n    <\/article>\n                                    <article class=\"news-card overflow-hidden\">\n            \n                            <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/purification-continue-par-echange-danions-dun-sirna-conjugue\/\" class=\"block relative w-full aspect-[4\/3] overflow-hidden mb-fluid-s-plus\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2025\/12\/Gemini_Generated_Image_ldccdzldccdzldcc-768x768.jpg\"\n                    alt=\"Purification continue par \u00e9change d&rsquo;anions d&rsquo;un siRNA conjugu\u00e9\"\n                    class=\"w-full h-full object-cover !m-0\"\n                    loading=\"lazy\" \/>\n            <\/a>\n        \n                <div class=\"flex gap-3 items-center mb-fluid-xs\">\n                            <span class=\"px-fluid-3xs py-2.5 bg-[#EEF5FE] text-secondary-700 text-s rounded-full\">\n                    Purification d\u2019oligo                <\/span>\n                        <span class=\"text-secondary-700 text-s border border-gray-50 rounded-full px-fluid-3xs py-2.5\">\n                27 Ao\u00fbt 2026            <\/span>\n        <\/div>\n\n                <div class=\"\">\n                            <h3 class=\"heading-h4 !m-0 pb-fluid-xs typo-off\">\n                    <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/purification-continue-par-echange-danions-dun-sirna-conjugue\/\" class=\"!no-underline\">\n                        Purification continue par \u00e9change d&rsquo;anions d&rsquo;un siRNA conjugu\u00e9                    <\/a>\n                <\/h3>\n            \n                            <p class=\"!mb-0\">\n                    Une m\u00e9thode discontinue d&#039;\u00e9change d&#039;anions \u00e9tablie pour un brin sens de siRNA conjugu\u00e9, convertie en MCSGP continue \u00e0 deux colonnes : 13 cycles, 27 \u00e9lutions de produit, et un rendement passant de 80 % \u00e0 93 % \u00e0 puret\u00e9 inchang\u00e9e \u2014 plus un processus assist\u00e9 par logiciel pour passer du chromatogramme discontinu \u00e0 la m\u00e9thode en cours d&#039;ex\u00e9cution.                <\/p>\n                    <\/div>\n\n    <\/article>\n                                    <article class=\"news-card overflow-hidden\">\n            \n                            <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/validation-de-la-mcsgp-caracterisation-du-procede-et-qualification-des-performances-du-procede-ppq-pour-la-purification-de-peptides\/\" class=\"block relative w-full aspect-[4\/3] overflow-hidden mb-fluid-s-plus\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2026\/01\/MG_3603-e1768337149203-768x612.jpg\"\n                    alt=\"Validation du proc\u00e9d\u00e9 MCSGP : caract\u00e9risation et PPQ \u00e0 l\u2019\u00e9chelle commerciale\"\n                    class=\"w-full h-full object-cover !m-0\"\n                    loading=\"lazy\" \/>\n            <\/a>\n        \n                <div class=\"flex gap-3 items-center mb-fluid-xs\">\n                            <span class=\"px-fluid-3xs py-2.5 bg-[#EEF5FE] text-secondary-700 text-s rounded-full\">\n                    Purification de peptides                <\/span>\n                        <span class=\"text-secondary-700 text-s border border-gray-50 rounded-full px-fluid-3xs py-2.5\">\n                26 Ao\u00fbt 2026            <\/span>\n        <\/div>\n\n                <div class=\"\">\n                            <h3 class=\"heading-h4 !m-0 pb-fluid-xs typo-off\">\n                    <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/validation-de-la-mcsgp-caracterisation-du-procede-et-qualification-des-performances-du-procede-ppq-pour-la-purification-de-peptides\/\" class=\"!no-underline\">\n                        Validation du proc\u00e9d\u00e9 MCSGP : caract\u00e9risation et PPQ \u00e0 l\u2019\u00e9chelle commerciale                    <\/a>\n                <\/h3>\n            \n                            <p class=\"!mb-0\">\n                    La chromatographie continue est d\u00e9j\u00e0 utilis\u00e9e en production, mais il n\u2019existait aucune publication sur la mani\u00e8re de la valider pour un d\u00e9p\u00f4t r\u00e9glementaire. Cette \u00e9tude en fournit une, en d\u00e9taillant la caract\u00e9risation du proc\u00e9d\u00e9 et la qualification des performances du proc\u00e9d\u00e9 (PPQ) pour la MCSGP appliqu\u00e9e \u00e0 la purification de la Bivalirudine \u00e0 l\u2019\u00e9chelle commerciale : 34 param\u00e8tres \u00e9valu\u00e9s, quatre test\u00e9s, un critique.                 <\/p>\n                    <\/div>\n\n    <\/article>\n                                    <article class=\"news-card overflow-hidden\">\n            \n                            <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/la-chromatographie-a-contre-courant-mcsgp-permet-lutilisation-de-solvants-verts-pour-des-procedes-productifs-de-purification-de-peptides\/\" class=\"block relative w-full aspect-[4\/3] overflow-hidden mb-fluid-s-plus\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2026\/08\/Green-Solvents-MCSCP-Cover-Image-e1787732926540-768x598.jpg\"\n                    alt=\"Purification de peptides sans ac\u00e9tonitrile ni TFA avec MCSGP\"\n                    class=\"w-full h-full object-cover !m-0\"\n                    loading=\"lazy\" \/>\n            <\/a>\n        \n                <div class=\"flex gap-3 items-center mb-fluid-xs\">\n                            <span class=\"px-fluid-3xs py-2.5 bg-[#EEF5FE] text-secondary-700 text-s rounded-full\">\n                    Purification de peptides                <\/span>\n                        <span class=\"text-secondary-700 text-s border border-gray-50 rounded-full px-fluid-3xs py-2.5\">\n                25 Ao\u00fbt 2026            <\/span>\n        <\/div>\n\n                <div class=\"\">\n                            <h3 class=\"heading-h4 !m-0 pb-fluid-xs typo-off\">\n                    <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/la-chromatographie-a-contre-courant-mcsgp-permet-lutilisation-de-solvants-verts-pour-des-procedes-productifs-de-purification-de-peptides\/\" class=\"!no-underline\">\n                        Purification de peptides sans ac\u00e9tonitrile ni TFA avec MCSGP                    <\/a>\n                <\/h3>\n            \n                            <p class=\"!mb-0\">\n                    Les solvants verts ont toujours p\u00e9nalis\u00e9 la r\u00e9cup\u00e9ration dans l\u2019industrie des peptides. Cette \u00e9tude montre que la perte est une propri\u00e9t\u00e9 de la chromatographie discontinue, et non du solvant : utilisez le m\u00eame \u00e9luant vert \u00e0 contre-courant et le rendement revient.                 <\/p>\n                    <\/div>\n\n    <\/article>\n                                    <article class=\"news-card overflow-hidden\">\n            \n                            <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/partie-i-quest-ce-que-la-chromatographie-une-introduction-aux-essentiels\/\" class=\"block relative w-full aspect-[4\/3] overflow-hidden mb-fluid-s-plus\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2025\/11\/chromatography-essentials-768x600.jpg\"\n                    alt=\"Qu\u2019est-ce que la chromatographie ? Une introduction aux essentiels\"\n                    class=\"w-full h-full object-cover !m-0\"\n                    loading=\"lazy\" \/>\n            <\/a>\n        \n                <div class=\"flex gap-3 items-center mb-fluid-xs\">\n                            <span class=\"px-fluid-3xs py-2.5 bg-[#EEF5FE] text-secondary-700 text-s rounded-full\">\n                    Fondamentaux de la chromatographie pr\u00e9parative                <\/span>\n                        <span class=\"text-secondary-700 text-s border border-gray-50 rounded-full px-fluid-3xs py-2.5\">\n                13 Mai 2026            <\/span>\n        <\/div>\n\n                <div class=\"\">\n                            <h3 class=\"heading-h4 !m-0 pb-fluid-xs typo-off\">\n                    <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/partie-i-quest-ce-que-la-chromatographie-une-introduction-aux-essentiels\/\" class=\"!no-underline\">\n                        Qu\u2019est-ce que la chromatographie ? Une introduction aux essentiels                    <\/a>\n                <\/h3>\n            \n                            <p class=\"!mb-0\">\n                    Un guide pratique sur la chromatographie : ce que c\u2019est, comment cela fonctionne et pourquoi c\u2019est important. D\u00e9couvrez les principaux m\u00e9canismes de s\u00e9paration, notamment la chromatographie en phase inverse, par \u00e9change d\u2019ions, par exclusion de taille et par affinit\u00e9, ainsi que la lecture des chromatogrammes et la diff\u00e9rence entre les m\u00e9thodes analytiques et pr\u00e9paratives.                 <\/p>\n                    <\/div>\n\n    <\/article>\n                                    <article class=\"news-card overflow-hidden\">\n            \n                            <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/partie-ii-quest-ce-que-la-chromatographie-preparative\/\" class=\"block relative w-full aspect-[4\/3] overflow-hidden mb-fluid-s-plus\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2025\/11\/Gemini_Generated_Image_4g7i124g7i124g7i-e1765294688698-768x598.jpg\"\n                    alt=\"Qu\u2019est-ce que la chromatographie pr\u00e9parative ? Analytique vs pr\u00e9parative \u2014 explications\"\n                    class=\"w-full h-full object-cover !m-0\"\n                    loading=\"lazy\" \/>\n            <\/a>\n        \n                <div class=\"flex gap-3 items-center mb-fluid-xs\">\n                            <span class=\"px-fluid-3xs py-2.5 bg-[#EEF5FE] text-secondary-700 text-s rounded-full\">\n                    Fondamentaux de la chromatographie pr\u00e9parative                <\/span>\n                        <span class=\"text-secondary-700 text-s border border-gray-50 rounded-full px-fluid-3xs py-2.5\">\n                13 Mai 2026            <\/span>\n        <\/div>\n\n                <div class=\"\">\n                            <h3 class=\"heading-h4 !m-0 pb-fluid-xs typo-off\">\n                    <a href=\"https:\/\/www.chromacon.com\/fr\/articles\/partie-ii-quest-ce-que-la-chromatographie-preparative\/\" class=\"!no-underline\">\n                        Qu\u2019est-ce que la chromatographie pr\u00e9parative ? Analytique vs pr\u00e9parative \u2014 explications                    <\/a>\n                <\/h3>\n            \n                            <p class=\"!mb-0\">\n                    La chromatographie analytique produit des donn\u00e9es ; la chromatographie pr\u00e9parative produit de la mati\u00e8re purifi\u00e9e. Ce guide explique les principales diff\u00e9rences d\u2019objectifs, d\u2019\u00e9chelle, de conception des colonnes et de strat\u00e9gies d\u2019optimisation, et pourquoi chaque \u00e9tape pr\u00e9parative est un \u00e9quilibre entre des objectifs concurrents \u2014 puret\u00e9, rendement et d\u00e9bit.                 <\/p>\n                    <\/div>\n\n    <\/article>\n                            <\/div>\n            \n                                        \n            <\/div>\n    \n    <\/div><\/section><section id=\"block_f0f2df7a2cf881b416f5ab6c7000aaf8\" class=\"block-call-to-action py-fluid-6xl bg-secondary-700 alignfull  \" style=\"--block-bg-image: url(https:\/\/www.chromacon.com\/wp-content\/themes\/chromacon\/assets\/img\/layout\/block-background-poly.svg);\"><div class=\"l-wrap\">\n    <div class=\"flex flex-col gap-6 items-center text-center\">\n                    <p class=\"heading-display-m mx-auto !text-white !my-0 max-w-[1015px]\">\n                Vous avez un d\u00e9fi de purification sp\u00e9cifique ?            <\/p>\n        \n                    <div class=\"block-call-to-action__buttons mt-fluid-m flex flex-row flex-wrap justify-center items-center gap-[30px]\">\n                <span class=\"c-btn-focus-wrapper\"><a href=\"#contact-form\" class=\"c-btn c-btn--regular c-btn--primary c-btn--light\" style=\"--bg-color: var(--color-primary-800); --border-color: var(--color-primary-800); --bg-hover-color: var(--color-primary-700); --border-hover-color: var(--color-primary-700);\"><span>Parlez \u00e0 un expert<\/span><\/a><\/span>                <span class=\"c-btn-focus-wrapper\"><a href=\"https:\/\/www.chromacon.com\/fr\/ressources\/\" class=\"c-btn c-btn--regular c-btn--secondary c-btn--dark\"><span>Parcourir la biblioth\u00e8que de ressources<\/span><\/a><\/span>            <\/div>\n        \n            <\/div>\n\n    <\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":16885,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_titles_title":"Articles et analyses sur la chromatographie | YMC ChromaCon","_seopress_titles_desc":"Articles techniques, analyses et commentaires sur la chromatographie continue, l'intensification des processus et le bioproc\u00e9d\u00e9 en aval de YMC ChromaCon.","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"footnotes":""},"class_list":["post-16884","page","type-page","status-publish","has-post-thumbnail",""],"acf":[],"_links":{"self":[{"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/pages\/16884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/comments?post=16884"}],"version-history":[{"count":2,"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/pages\/16884\/revisions"}],"predecessor-version":[{"id":17799,"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/pages\/16884\/revisions\/17799"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/media\/16885"}],"wp:attachment":[{"href":"https:\/\/www.chromacon.com\/fr\/wp-json\/wp\/v2\/media?parent=16884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}