{"id":1871,"date":"2025-11-17T11:34:29","date_gmt":"2025-11-17T11:34:29","guid":{"rendered":"https:\/\/chromocan.test\/service\/feasibility-studies\/"},"modified":"2026-05-07T14:22:19","modified_gmt":"2026-05-07T12:22:19","slug":"feasibility-studies","status":"publish","type":"service","link":"https:\/\/www.chromacon.com\/en\/services\/feasibility-studies\/","title":{"rendered":"Feasibility Studies"},"content":{"rendered":"
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\n FEASIBILITY STUDIES <\/p>\n \n

\n See the Improvement Before You Commit\n <\/h1>\n \n
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CaptureSMB\u00ae and MCSGP feasibility studies. A 4\u20136 week, molecule-specific benchmark against your existing batch process \u2014 on your resin, with your feed, under your conditions. You receive quantified productivity, yield, buffer consumption, and IPC reduction data \u2014 not assumptions.<\/p>\n <\/div>\n <\/div>\n\n

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\n Request a Feasibility Study<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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\n Request a Feasibility Study<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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\n Hard Data on Your Molecule <\/h2>\n \n
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You know your batch chromatography process works. The question is whether continuous chromatography can make it work significantly better \u2014 higher productivity, better resin utilization, lower buffer consumption \u2014 without compromising yield or product quality.<\/p>\n

A YMC ChromaCon feasibility study answers that question with hard data. We take your existing method, reproduce it on our Contichrom\u00ae platform to establish a fair benchmark, and then run the equivalent process in continuous mode. You receive a side-by-side comparison with real performance metrics from your molecule, on your resin, under your conditions.<\/p>\n

Feasibility studies are available for two continuous chromatography technologies, each addressing a different part of the downstream process:<\/p>\n <\/div>\n \n <\/div>\n\n

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\n \n CaptureSMB\u00ae \u2014 Continuous Capture <\/a>\n <\/h3>\n \n

\n Twin-column periodic counter-current (PCC) chromatography for affinity and bind-elute capture steps. CaptureSMB\u00ae maximises resin utilisation by loading one column while the other is being washed, eluted, and regenerated \u2014 with product breakthrough from the first column captured on the second.
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\r\nBest suited for:
\r\nProtein A capture of monoclonal antibodies, affinity chromatography for hormones and recombinant proteins, and other bind-elute steps where resin cost or throughput is a bottleneck. <\/p>\n \n

\n Learn More About CaptureSMB\u00ae + AutomAb\u00ae<\/span><\/a><\/span> <\/div>\n \n <\/div>\n\n<\/div>\n\n <\/div><\/section><\/div>\n\n\n\n
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\n \n MCSGP \u2014 Continuous Polishing <\/a>\n <\/h3>\n \n

\n Multicolumn counter-current solvent gradient purification for difficult separations where batch chromatography faces a tradeoff between yield and purity. MCSGP recycles impure side fractions automatically, achieving high purity and high yield simultaneously.
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\r\nBest suited for:
\r\nCharge variant and isoform fractionation (IEX), oligonucleotide purification (AEX), small-molecule and peptide polishing (RP), and any gradient-based separation where the product peak overlaps with closely eluting impurities. <\/p>\n \n

\n Learn More About MCSGP + AutoPeak\u00ae<\/span><\/a><\/span> <\/div>\n \n <\/div>\n\n<\/div>\n\n <\/div><\/section><\/div>\n<\/div>\n\n\n
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