{"id":8859,"date":"2026-05-10T10:25:52","date_gmt":"2026-05-10T08:25:52","guid":{"rendered":"https:\/\/www.chromacon.com\/?p=8859"},"modified":"2026-05-19T13:39:30","modified_gmt":"2026-05-19T11:39:30","slug":"iopc-2026-athens","status":"publish","type":"post","link":"https:\/\/www.chromacon.com\/en\/news\/iopc-2026-athens\/","title":{"rendered":"IOPC 2026 \u2014 YMC ChromaCon at the International Oligonucleotides &amp; Peptides Conference, Athens"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">YMC ChromaCon at IOPC 2026 \u2014 Athens, 9\u201311 June<\/h2>\n\n\n\n<p class=\"is-style-default has-text-l-font-size\"><em>The 7th International Oligonucleotides and Peptides Conference. New data on AutoPeak\u00ae dynamic process control and green-solvent MCSGP for sustainable peptide and oligonucleotide manufacturing.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Event at a Glance<\/h2>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Event<\/strong><\/td><td>IOPC 2026 \u2014 7th International Oligonucleotides and Peptides Conference<\/td><\/tr><tr><td><strong>Dates<\/strong><\/td><td>9\u201311 June 2026<\/td><\/tr><tr><td><strong>Venue<\/strong><\/td><td>Titania Hotel, Athens, Greece<\/td><\/tr><tr><td><strong>YMC ChromaCon focus<\/strong><\/td><td>MCSGP continuous polishing with AutoPeak\u00ae dynamic control \u2014 for peptides, GLP-1s, and oligonucleotides<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Our Talk<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Dynamic Process Control and Use of Green Solvents in Continuous Chromatography (MCSGP)<\/h3>\n\n\n\n<p><strong>Wednesday, 10 June 2026 \u2014 17:05\u201317:35<\/strong> \u00b7 Peptides track<\/p>\n\n\n\n<p><strong>Dr. Thomas M\u00fcller-Sp\u00e4th<\/strong> \u2014 CEO and co-founder, ChromaCon AG, a YMC company<\/p>\n\n\n\n<p>MCSGP is increasingly adopted across the pharmaceutical industry for the purification of synthetic peptides and oligonucleotides. In the context of GLP-1 peptide manufacturing in particular, MCSGP addresses the core challenges of scalability, automation, and sustainability \u2014 through its process principle of automatic, in-line side-cut recycling.<\/p>\n\n\n\n<p>This presentation covers two developments that decide whether an MCSGP process is genuinely production-ready:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AutoPeak\u00ae \u2014 UV-based dynamic process control. <\/strong>AutoPeak\u00ae is the proprietary closed-loop control technology required to run MCSGP reliably at manufacturing scale. It monitors the elution profile in real time at the column outlet and adjusts product collection windows cycle-by-cycle to compensate for retention time drift, column aging, and starting-material variability. Without AutoPeak\u00ae, fixed-time MCSGP cannot deliver consistent purity and yield across hundreds of cycles. The talk covers practical implementation guidance for designing robust, drift-tolerant AutoPeak\u00ae-controlled MCSGP processes.<\/li>\n\n\n\n<li><strong>Green solvents for MCSGP. <\/strong>A case study demonstrating MCSGP with green solvents \u2014 maintaining the yield and purity that batch chromatography typically forfeits when fluorinated solvents are removed. The findings are directly relevant to the reduction of hazardous waste and the elimination of PFAS (forever chemicals) from peptide and oligonucleotide manufacturing.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Why It Matters<\/h2>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><thead><tr><td>&nbsp;<\/td><td><strong>Without AutoPeak\u00ae<\/strong><\/td><td><strong>MCSGP with AutoPeak\u00ae<\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Manufacturing operation<\/strong><\/td><td>Fixed-time windows; manual intervention as retention times drift<\/td><td>Closed-loop UV-triggered windows; consistent across hundreds of cycles<\/td><\/tr><tr><td><strong>Response to feed variability<\/strong><\/td><td>Yield loss or purity excursion<\/td><td>Automatic compensation, cycle-by-cycle<\/td><\/tr><tr><td><strong>Solvent footprint<\/strong><\/td><td>High; often PFAS-containing<\/td><td>Up to 75% reduction; PFAS-free solvent systems demonstrated<\/td><\/tr><tr><td><strong>Regulatory positioning<\/strong><\/td><td>Manual control burdens validation<\/td><td>AutoPeak\u00ae validated as Process Analytical Technology (PAT)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Meet Us in Athens<\/h2>\n\n\n\n<p>Dr. Thomas M\u00fcller-Sp\u00e4th and the YMC ChromaCon team will be available throughout IOPC 2026 to discuss:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>MCSGP for <strong>GLP-1 and complex peptide<\/strong> manufacturing \u2014 process design and scale-up<\/li>\n\n\n\n<li>AEX MCSGP for <strong>synthetic oligonucleotides<\/strong> \u2014 ASOs, siRNA, GalNAc conjugates<\/li>\n\n\n\n<li><strong>Green-solvent MCSGP<\/strong> workflows and PFAS-elimination strategies<\/li>\n\n\n\n<li>The <strong>Contichrom\u00ae CUBE<\/strong> for process development, scale-up to <strong>Contichrom\u00ae PILOT 300X<\/strong> and <strong>Contichrom\u00ae TWIN HPLC<\/strong> for GMP manufacturing<\/li>\n\n\n\n<li>Feasibility studies, rental options, and on-site demos at our Zurich facility<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">About the Speaker<\/h2>\n\n\n\n<p class=\"is-style-default has-text-l-font-size\"><strong>Dr. Thomas M\u00fcller-Sp\u00e4th<\/strong> is CEO and co-founder of ChromaCon AG, a YMC company. He has led the development of MCSGP, AutoPeak\u00ae, and N-Rich\u00ae from research concept to GMP-validated commercial technology, including the first published Process Characterization and Performance Qualification framework for MCSGP (Eisenhuth &amp; M\u00fcller-Sp\u00e4th, <em>Processes<\/em> 2025, with Bachem on the bivalirudin programme).<\/p>\n\n\n<section id=\"block_6e6ae0c0739ca9df902a8ea34219c4ff\" class=\"block-faq py-fluid-4xl alignfull  \"><div class=\"l-wrap\">\n            <div class=\"block-faq__header mb-fluid-m md:mb-fluid-3xl typo-off\">\n                            <h2 class=\"text-display-m leading-display-m leading-h1 md:text-h1 text-primary-800 text-center mb-fluid-xs\">Frequently Asked Questions<\/h2>\n                                <\/div>\n    \n            <div class=\"block-faq__accordion js-block-faq-accordion flex flex-col gap-fluid-s\">\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-0\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-0-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-0-content\"\n                        aria-label=\"Toggle question: What is YMC ChromaCon presenting at IOPC 2026?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What is YMC ChromaCon presenting at IOPC 2026?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-0-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-0-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Dr. Thomas M\u00fcller-Sp\u00e4th, CEO and co-founder of ChromaCon AG (a YMC company), will present &#8220;Dynamic Process Control and Use of Green Solvents in Continuous Chromatography (MCSGP)&#8221; on Wednesday 10 June at 17:05 in the peptides track. The talk covers AutoPeak\u00ae \u2014 our proprietary closed-loop control technology for MCSGP manufacturing \u2014 and a case study on green-solvent MCSGP that eliminates PFAS without sacrificing yield or purity.<\/p>\n<p>&nbsp;<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-1\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-1-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-1-content\"\n                        aria-label=\"Toggle question: Why is AutoPeak\u00ae required for MCSGP manufacturing?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Why is AutoPeak\u00ae required for MCSGP manufacturing?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-1-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-1-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>MCSGP is a cyclic process that runs for hundreds or thousands of switches across a campaign. Retention times drift as columns age, feed varies, and buffer batches change. Fixed-time collection windows cannot accommodate this. AutoPeak\u00ae monitors the UV elution profile at the column outlet in real time and adjusts the product collection window cycle-by-cycle, keeping every cycle on target. It is validated as a Process Analytical Technology (PAT) and is what takes MCSGP from development-ready to production-ready.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-2\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-2-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-2-content\"\n                        aria-label=\"Toggle question: What does &quot;green solvents for MCSGP&quot; mean in practice?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What does &quot;green solvents for MCSGP&quot; mean in practice?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-2-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-2-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Many established peptide and oligonucleotide RP-HPLC methods rely on fluorinated additives, including PFAS-class &#8220;forever chemicals&#8221;. Removing them in a batch process typically costs yield or purity. The case study presented at IOPC shows that with MCSGP and AutoPeak\u00ae control, the same separation can be performed with green solvents \u2014 without the yield and purity loss that batch chromatography typically forfeits when fluorinated solvents are eliminated. This directly addresses hazardous-waste reduction and PFAS-elimination targets in pharmaceutical manufacturing.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-3\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-3-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-3-content\"\n                        aria-label=\"Toggle question: How is MCSGP with AutoPeak\u00ae relevant to GLP-1 peptide manufacturing?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How is MCSGP with AutoPeak\u00ae relevant to GLP-1 peptide manufacturing?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-3-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-3-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>GLP-1 agonists like semaglutide and tirzepatide are long-chain peptides with complex impurity profiles and very high commercial volumes. Batch RP-HPLC forces a purity\u2013yield trade-off and consumes large solvent volumes. MCSGP recycles impure side-fractions internally, recovering peptide product that batch processes discard, with up to 75% less solvent. AutoPeak\u00ae keeps the process consistent across long manufacturing campaigns. For GLP-1 manufacturing this addresses scalability, automation, and sustainability simultaneously.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-4\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-4-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-4-content\"\n                        aria-label=\"Toggle question: Has MCSGP been validated under GMP?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Has MCSGP been validated under GMP?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-4-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-4-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Yes. Bachem has run GMP MCSGP peptide manufacturing since 2022. The first published Process Characterization and Performance Qualification framework for MCSGP \u2014 <strong>Eisenhuth and M\u00fcller-Sp\u00e4th, <span class=\"token token italic\">_<\/span><span class=\"token token italic content\">Processes<\/span><span class=\"token token italic\">_<\/span> 13(12):3950 (2025)<\/strong> \u2014 was demonstrated on the 20-mer peptide Bivalirudin and showed 62% gross-to-gross yield, greater than 99.0% purity across all PPQ batches, a 95% reduction in in-process controls versus batch, and PMI reduced from approximately 5,200 to 1,400 kg\/kg. AutoPeak\u00ae was validated as a PAT in the same programme.<\/p>\n                            \n                                                                                        <div class=\"mt-fluid-m\">\n                                    <span class=\"c-btn-focus-wrapper\"><a href=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2026\/01\/processes-13-03950-v2.pdf\" class=\"c-btn c-btn--regular c-btn--primary c-btn--light\" download><span>Download the PPQ Paper<\/span><\/a><\/span>                                <\/div>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-5\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-5-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-5-content\"\n                        aria-label=\"Toggle question: Does MCSGP also work for synthetic oligonucleotides?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Does MCSGP also work for synthetic oligonucleotides?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-5-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-5-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Yes. MCSGP runs on the same hardware for both peptides (RP-HPLC mode) and oligonucleotides (AEX or IP-RP mode). It has been applied to antisense oligonucleotides, siRNA, and GalNAc conjugates. Recent published data on a siRNA conjugate (<strong>Weldon et al., <span class=\"token token italic\">_<\/span><span class=\"token token italic content\">Organic Process Research &amp; Development<\/span><span class=\"token token italic\">_<\/span> 29:1400, 2025<\/strong>) showed a yield increase from 80% to 93% by AEX MCSGP.<\/p>\n                            \n                                                                                        <div class=\"mt-fluid-m\">\n                                    <span class=\"c-btn-focus-wrapper\"><a href=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2025\/12\/2025_Weldon_Continuous-purification-of-a-conjugated-siRNA_MCSGP.pdf\" class=\"c-btn c-btn--regular c-btn--primary c-btn--light\" download><span>Download the Paper<\/span><\/a><\/span>                                <\/div>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-6\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-6-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-6-content\"\n                        aria-label=\"Toggle question: How can I meet the YMC ChromaCon team during IOPC 2026?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How can I meet the YMC ChromaCon team during IOPC 2026?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-6-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_6e6ae0c0739ca9df902a8ea34219c4ff-6-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Dr. Thomas M\u00fcller-Sp\u00e4th and the YMC ChromaCon team will be available throughout the three days in Athens. Use the contact form on this page to request a meeting slot. We can discuss MCSGP for your specific peptide or oligonucleotide programme, green-solvent workflows, feasibility studies at our Zurich facility, Contichrom\u00ae CUBE rental, or scale-up to the Contichrom\u00ae PILOT 300X and Contichrom\u00ae TWIN HPLC.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                    <\/div>\n    \n<\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>Meet YMC ChromaCon at IOPC 2026 in Athens, 9\u201311 June. CEO Dr. Thomas M\u00fcller-Sp\u00e4th presents new data on AutoPeak\u00ae dynamic process control and green solvents for MCSGP \u2014 for robust, sustainable, PFAS-free peptide and oligonucleotide manufacturing.<\/p>\n","protected":false},"author":2,"featured_media":8858,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"288","_seopress_titles_title":"IOPC 2026 \u2014 YMC ChromaCon at the International Oligonucleotides & Peptides Conference, Athens","_seopress_titles_desc":"Meet YMC ChromaCon at IOPC 2026 in Athens, 9\u201311 June. CEO Dr. Thomas M\u00fcller-Sp\u00e4th presents new data on AutoPeak\u00ae dynamic process control and green solvents for MCSGP \u2014 for robust, sustainable, PFAS-free peptide and oligonucleotide manufacturing.","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"categories":[288],"tags":[290],"class_list":["post-8859","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-events","tag-iopc-conference"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/8859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/comments?post=8859"}],"version-history":[{"count":8,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/8859\/revisions"}],"predecessor-version":[{"id":8914,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/8859\/revisions\/8914"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media\/8858"}],"wp:attachment":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media?parent=8859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/categories?post=8859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/tags?post=8859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}