{"id":1470,"date":"2025-08-28T14:01:00","date_gmt":"2025-08-28T14:01:00","guid":{"rendered":"https:\/\/www.chromacon.com\/?p=1470"},"modified":"2026-04-26T20:26:29","modified_gmt":"2026-04-26T18:26:29","slug":"ymc-chromacon-announces-contichrom-pilot-300x-a-new-standard-in-pilot-scale-continuous-chromatography","status":"publish","type":"post","link":"https:\/\/www.chromacon.com\/en\/news\/ymc-chromacon-announces-contichrom-pilot-300x-a-new-standard-in-pilot-scale-continuous-chromatography\/","title":{"rendered":"YMC ChromaCon Announces Contichrom\u00ae PILOT 300X \u2014 A New Standard in Pilot-Scale Continuous Chromatography"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Contichrom\u00ae PILOT 300X \u2013 Pilot-Scale Continuous Chromatography for GMP Manufacturing<\/h2>\n\n\n\n<p>The Contichrom\u00ae PILOT 300X is YMC ChromaCon\u2019s next-generation preparative HPLC system for pilot-scale continuous purification in fully regulated GMP environments. Built around patented twin-column MCSGP technology with AutoPeak\u00ae, it enables high purity and high yield at the same time, while reducing solvent consumption and overall Process Mass Intensity (PMI).<\/p>\n\n\n\n<p>Available from 2026, the Contichrom\u00ae PILOT 300X is designed for peptides, oligonucleotides, and other high-value synthetic molecules that demand robust, scalable, and compliant purification from lab development through to commercial manufacturing.<\/p>\n\n\n\n<p><strong>Key benefits at a glance:<\/strong> continuous chromatography with automated fraction recycling, GMP-ready hardware and software, reduced solvent use, higher productivity, and seamless scale-up to Contichrom\u00ae TWIN production systems.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Is the Contichrom\u00ae PILOT 300X?<\/h2>\n\n\n\n<p>The Contichrom\u00ae PILOT 300X is a pilot-scale, twin-column preparative HPLC system that brings continuous chromatography into GMP manufacturing. It integrates ChromaCon\u2019s proprietary Multicolumn Counter-Current Solvent Gradient Purification (MCSGP) technology with AutoPeak\u00ae control to overcome the classic purity\u2013yield\u2013throughput trade-off in batch chromatography. Instead of discarding valuable side fractions, the system automatically recycles and re-separates them, recovering more product at target purity and significantly cutting re-chromatography.<\/p>\n\n\n\n<p>Designed for both aqueous and organic solvent processes, the Contichrom\u00ae PILOT 300X supports modern high-performance resins in reversed-phase and ion-exchange chromatography, providing a flexible platform for a broad range of synthetic APIs and advanced intermediates.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Engineered for Demanding Pilot-Scale Purification<\/h2>\n\n\n\n<p>The Contichrom\u00ae PILOT 300X translates laboratory-process understanding into reliable pilot-scale manufacturing. With a maximum operating pressure of 100 bar and flow rates up to 300 mL\/min, it is optimized for columns up to 10 cm inner diameter, supporting fast, efficient methods for complex separations.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Twin-column continuous operation:<\/strong> MCSGP with AutoPeak\u00ae for automated internal recycling of impure side fractions.<\/li>\n\n\n\n<li><strong>Pilot-scale performance:<\/strong> up to 300 mL\/min flow and 100 bar maximum pressure for modern, high-efficiency resins.<\/li>\n\n\n\n<li><strong>Flexible chemistry:<\/strong> compatible with aqueous and organic solvents for peptides, oligonucleotides, and small molecules.<\/li>\n\n\n\n<li><strong>Hazardous area certification:<\/strong> fully certified for ATEX Zone 2 and Class I Division 2 environments.<\/li>\n\n\n\n<li><strong>24\/7 automation:<\/strong> robust hardware and software for unattended continuous operation.<\/li>\n<\/ul>\n\n\n\n<p>By combining these capabilities, the Contichrom\u00ae PILOT 300X provides a bridge between benchtop development and production-scale continuous chromatography, allowing process teams to lock in scalable conditions early in development.<\/p>\n\n\n\n<figure class=\"wp-block-video alignwide\"><video height=\"1088\" style=\"aspect-ratio: 1920 \/ 1088;\" width=\"1920\" controls muted src=\"https:\/\/www.chromacon.com\/wp-content\/uploads\/2025\/08\/A_slow_panning_202512021006-1.mp4\" playsinline><\/video><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">MCSGP with AutoPeak\u00ae \u2013 High Purity and High Yield at Once<\/h2>\n\n\n\n<p>Traditional single-column batch chromatography forces a compromise: either collect narrow center cuts for high purity and lose yield, or widen fraction windows to increase recovery at the expense of purity. MCSGP (Multicolumn Counter-Current Solvent Gradient Purification) in the Contichrom\u00ae PILOT 300X changes this equation.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Automated side-fraction recycling:<\/strong> overlapping \u201cshoulder\u201d fractions are automatically redirected to a second column, rather than being discarded or manually reprocessed.<\/li>\n\n\n\n<li><strong>Dynamic collection windows:<\/strong> AutoPeak\u00ae continuously adapts fraction boundaries in real time, ensuring robust collection of in-spec product as process conditions evolve.<\/li>\n\n\n\n<li><strong>Higher productivity:<\/strong> more aggressive loading and gradients are possible, increasing throughput while preserving the required purity.<\/li>\n<\/ul>\n\n\n\n<p>The result is a continuous chromatography process that delivers high purity and high yield simultaneously, with fewer manual interventions and less solvent usage compared to conventional batch methods.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2D Integrated Chromatography for Complex Purifications<\/h2>\n\n\n\n<p>Beyond continuous MCSGP operation, the twin-column architecture of the Contichrom\u00ae PILOT 300X enables true 2D integrated chromatography. Two different purification modes (for example, reversed phase followed by anion exchange) can be combined into a single automated process.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Integrated two-step purification:<\/strong> link two orthogonal methods in one continuous workflow.<\/li>\n\n\n\n<li><strong>Reduced intermediate handling:<\/strong> minimize pooling, transfers, and storage between steps.<\/li>\n\n\n\n<li><strong>Smaller facility footprint:<\/strong> fewer unit operations and reduced equipment count.<\/li>\n\n\n\n<li><strong>Improved data integrity:<\/strong> continuous, fully traceable data capture from feed to final pool.<\/li>\n<\/ul>\n\n\n\n<p>This integrated approach is particularly valuable for complex molecules where a single chromatographic step cannot simultaneously achieve all required specifications.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">GMP-Ready Automation with ChromIQ\u00ae X<\/h2>\n\n\n\n<p>The Contichrom\u00ae PILOT 300X is powered by ChromIQ\u00ae X, a modern control platform developed under GAMP 5 principles and designed to support 21 CFR Part 11 compliance. It delivers the level of electronic control and data integrity expected in regulated GMP manufacturing.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Full traceability:<\/strong> detailed audit trails for methods, batches, and user actions.<\/li>\n\n\n\n<li><strong>Secure data handling:<\/strong> controlled user access, electronic signatures, and compliant data storage.<\/li>\n\n\n\n<li><strong>Advanced visualization:<\/strong> real-time monitoring of continuous runs, column performance, and critical process parameters.<\/li>\n\n\n\n<li><strong>Method lifecycle support:<\/strong> straightforward transfer and version control from development to commercial production.<\/li>\n<\/ul>\n\n\n\n<p>Together, the hardware and software form a complete solution for GMP-compliant continuous chromatography at pilot scale.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Seamless Scale-Up from Contichrom\u00ae CUBE to Production<\/h2>\n\n\n\n<p>Methods developed on the laboratory-scale Contichrom\u00ae CUBE can be transferred efficiently to the Contichrom\u00ae PILOT 300X, simplifying scale-up and reducing tech-transfer risk. The same core MCSGP and AutoPeak\u00ae concepts are preserved, enabling a consistent development pathway from first feasibility to commercial production.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Predictable scale-up:<\/strong> maintain chromatographic selectivity while scaling column dimensions and flow rates.<\/li>\n\n\n\n<li><strong>Shorter development timelines:<\/strong> reuse proven method strategies and templates across scales.<\/li>\n\n\n\n<li><strong>Production-ready architecture:<\/strong> pilot-scale experience translates directly to Contichrom\u00ae TWIN production systems.<\/li>\n<\/ul>\n\n\n\n<p>This integrated platform approach allows organizations to invest once in a continuous chromatography strategy and extend it across the entire lifecycle of a molecule.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Availability and How to Request a Quote<\/h2>\n\n\n\n<p>The Contichrom\u00ae PILOT 300X will be commercially available from 2026. Process development teams and manufacturers can already begin planning their transition to continuous chromatography by requesting a budgetary quote today.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Website:<\/strong> <a href=\"https:\/\/www.chromacon.com\" target=\"_blank\" rel=\"noopener\">www.chromacon.com<\/a><\/li>\n\n\n\n<li><strong>Email:<\/strong> <a href=\"mailto:sales@chromacon.com\">sales@chromacon.com<\/a><\/li>\n<\/ul>\n\n\n\n<p>YMC ChromaCon is a pioneer in continuous chromatography solutions for biopharmaceutical and pharmaceutical purification. With technologies such as MCSGP, AutoPeak\u00ae, and N-Rich\u00ae, YMC ChromaCon helps customers achieve higher yields, improved purity, and more sustainable manufacturing processes.<\/p>\n\n\n<section id=\"block_fb802090c96288fe16104586f2b936e3\" class=\"block-faq py-fluid-4xl alignfull  \"><div class=\"l-wrap\">\n            <div class=\"block-faq__header mb-fluid-m md:mb-fluid-3xl typo-off\">\n                            <h2 class=\"text-display-m leading-display-m leading-h1 md:text-h1 text-primary-800 text-center mb-fluid-xs\">Frequently Asked Questions About the Contichrom\u00ae PILOT 300X<\/h2>\n                                <\/div>\n    \n            <div class=\"block-faq__accordion js-block-faq-accordion flex flex-col gap-fluid-s\">\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-0\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-0-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_fb802090c96288fe16104586f2b936e3-0-content\"\n                        aria-label=\"Toggle question: What applications is the Contichrom\u00ae PILOT 300X best suited for?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What applications is the Contichrom\u00ae PILOT 300X best suited for?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-0-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_fb802090c96288fe16104586f2b936e3-0-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>The Contichrom\u00ae PILOT 300X is designed for pilot-scale purification of high-value molecules such as peptides, oligonucleotides, and synthetic APIs. Its twin-column continuous architecture is ideal for challenging separations where traditional batch chromatography struggles to deliver the required combination of purity, yield, and throughput.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-1\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-1-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_fb802090c96288fe16104586f2b936e3-1-content\"\n                        aria-label=\"Toggle question: How does MCSGP improve yield compared to batch chromatography?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How does MCSGP improve yield compared to batch chromatography?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-1-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_fb802090c96288fe16104586f2b936e3-1-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>In batch chromatography, overlapping side fractions are often discarded or re-chromatographed manually, which reduces overall recovery and increases solvent consumption. MCSGP in the Contichrom\u00ae PILOT 300X automatically recycles these side fractions onto a second column, recovering additional in-spec product while still meeting purity specifications. This internal recycling is the key to achieving both high yield and high purity in a continuous process.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-2\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-2-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_fb802090c96288fe16104586f2b936e3-2-content\"\n                        aria-label=\"Toggle question: Is the Contichrom\u00ae PILOT 300X suitable for GMP manufacturing?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Is the Contichrom\u00ae PILOT 300X suitable for GMP manufacturing?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-2-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_fb802090c96288fe16104586f2b936e3-2-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Yes. The system is engineered for GMP-regulated environments. ChromIQ\u00ae X software is developed under a GAMP 5 framework and supports 21 CFR Part 11 compliance, including secure user management, electronic records, and full audit trails. This makes the Contichrom\u00ae PILOT 300X well suited for clinical and commercial manufacturing when deployed within an appropriate quality system.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-3\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-3-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_fb802090c96288fe16104586f2b936e3-3-content\"\n                        aria-label=\"Toggle question: Can the Contichrom\u00ae PILOT 300X be used in hazardous areas?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Can the Contichrom\u00ae PILOT 300X be used in hazardous areas?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-3-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_fb802090c96288fe16104586f2b936e3-3-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Yes. The hardware is certified for ATEX Zone 2 and Class I Division 2, enabling safe operation with flammable organic solvents in appropriate classified areas. This is particularly important for reversed-phase processes and other applications where organic solvents are routinely used at scale.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-4\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-4-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_fb802090c96288fe16104586f2b936e3-4-content\"\n                        aria-label=\"Toggle question: How do I transition methods from the Contichrom\u00ae CUBE to the PILOT 300X?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How do I transition methods from the Contichrom\u00ae CUBE to the PILOT 300X?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_fb802090c96288fe16104586f2b936e3-4-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_fb802090c96288fe16104586f2b936e3-4-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Methods developed on the Contichrom\u00ae CUBE can be scaled to the PILOT 300X by adjusting column dimensions, flow rates, and loadings while preserving the underlying MCSGP strategy and AutoPeak\u00ae control logic. ChromaCon provides guidance and documentation to support method transfer, helping teams move efficiently from lab feasibility to pilot scale and, ultimately, to Contichrom\u00ae TWIN production systems.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                    <\/div>\n    \n<\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>ChromaCon AG introduces the Contichrom\u00ae PILOT 300X, a next-generation preparative HPLC system for pilot-scale continuous chromatography in GMP environments. Powered by MCSGP technology with AutoPeak\u00ae control, it increases yield, purity and productivity while reducing solvent consumption.<\/p>\n","protected":false},"author":2,"featured_media":1509,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"categories":[159],"tags":[41],"class_list":["post-1470","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-news-events-cat","tag-pilot-300x-launch"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/comments?post=1470"}],"version-history":[{"count":17,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1470\/revisions"}],"predecessor-version":[{"id":6266,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1470\/revisions\/6266"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media\/1509"}],"wp:attachment":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media?parent=1470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/categories?post=1470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/tags?post=1470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}