{"id":1422,"date":"2018-02-13T15:27:00","date_gmt":"2018-02-13T15:27:00","guid":{"rendered":"https:\/\/www.chromacon.com\/?p=1422"},"modified":"2026-04-26T20:28:18","modified_gmt":"2026-04-26T18:28:18","slug":"chromacons-capturesmb-continuous-chromatography-process-scaled-from-laboratory-to-pilot-and-production","status":"publish","type":"post","link":"https:\/\/www.chromacon.com\/en\/news\/chromacons-capturesmb-continuous-chromatography-process-scaled-from-laboratory-to-pilot-and-production\/","title":{"rendered":"ChromaCon\u2019s CaptureSMB\u00ae Continuous Chromatography Process Scaled from Laboratory to Pilot and Production"},"content":{"rendered":"\n<p><strong>Zurich, Switzerland \u2013 February 13, 2018<\/strong> \u2013 ChromaCon AG today announced the successful scale-up of its <strong>CaptureSMB\u00ae twin-column periodic counter-current chromatography process<\/strong> for <strong>monoclonal antibody (mAb) purification<\/strong> from laboratory scale to industrial pilot and production scale.<\/p>\n\n\n\n<p>The <strong>CaptureSMB process<\/strong>, an optimized two-column periodic counter-current capture technology, has been transferred from a lab-scale <strong>Contichrom\u00ae CUBE<\/strong> system (ChromaCon, Zurich) to a 100-fold larger <strong>Contichrom\u00ae TWIN<\/strong> system (LEWA, Devens, MA). The results confirm that <strong>continuous Protein A capture<\/strong> with CaptureSMB can be reliably scaled for industrial bioprocessing.<\/p>\n\n\n\n<p>A joint team from <strong>Bristol-Myers Squibb (Devens, MA)<\/strong>, <strong>ChromaCon (Zurich)<\/strong> and <strong>LEWA (Devens, MA)<\/strong> reports these results in <em>BioProcess International<\/em> in the article <a href=\"http:\/\/bpi.bioprocessintl.com\/scale-up-of-twin-column-periodic-counter-current-chromatography-for-monoclonal-antibody-purification\" target=\"_blank\" rel=\"noopener\">\u201cScale-Up of Twin-Column Periodic Counter-Current Chromatography for Monoclonal Antibody Purification.\u201d<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Proven Industrial Scale-Up of CaptureSMB Continuous Capture<\/h3>\n\n\n\n<p>Lab-scale development work was carried out on a <strong>Contichrom CUBE<\/strong> system. The performance data from these <strong>small-scale CaptureSMB experiments<\/strong> accurately predicted the behavior of the process when transferred to <strong>pilot and production scale<\/strong> on the <strong>Contichrom TWIN<\/strong> platform, demonstrating a <strong>robust and seamless scale-up strategy<\/strong> for biopharmaceutical manufacturers.<\/p>\n\n\n\n<p>Compared with conventional <strong>single-column batch capture chromatography<\/strong>, the scaled CaptureSMB process delivered:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>2.5-fold higher productivity<\/strong> (increased grams of mAb produced per liter of resin per hour)<\/li>\n\n\n\n<li>Improved <strong>resin utilization from 67% to 92%<\/strong>, maximizing the value of chromatography media<\/li>\n\n\n\n<li>Approximately <strong>50% reduction in buffer consumption<\/strong>, lowering operating costs and facility footprint<\/li>\n<\/ul>\n\n\n\n<p>These performance gains support the adoption of <strong>continuous downstream processing<\/strong> and <strong>twin-column capture<\/strong> in commercial <strong>monoclonal antibody manufacturing<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Expert Perspective on Twin-Column Continuous Chromatography<\/h3>\n\n\n\n<p>Thomas M\u00fcller-Sp\u00e4th, COO of ChromaCon and co-author of the study, commented:<\/p>\n\n\n\n<p>\u201cThe data clearly show the benefit of a twin-column continuous capture process at production scale. The smooth and seamless upscaling process was facilitated by the low complexity of the twin-column CaptureSMB process. This is also an important factor when performing process validation and seeking regulatory approval.\u201d<\/p>\n\n\n\n<p>Michael Bavand, CEO of ChromaCon, added:<\/p>\n\n\n\n<p>\u201cThe validation of the CaptureSMB process performance at industrial scale represents a significant milestone for the bioprocess industry. Together with our partners we pave the way for a fast adoption of continuous processes at industrial scale.\u201d<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Key Benefits of CaptureSMB for Monoclonal Antibody Purification<\/h3>\n\n\n\n<p>The successful scale-up confirms CaptureSMB as a powerful <strong>continuous chromatography solution<\/strong> for mAb capture, offering:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Higher productivity<\/strong> compared to batch Protein A capture<\/li>\n\n\n\n<li><strong>Significantly improved resin utilization<\/strong>, extending resin lifetime and reducing cost of goods<\/li>\n\n\n\n<li><strong>Lower buffer consumption<\/strong> and smaller storage requirements<\/li>\n\n\n\n<li>A <strong>simple, two-column architecture<\/strong> that facilitates <strong>process validation<\/strong> and <strong>regulatory acceptance<\/strong><\/li>\n\n\n\n<li>Predictable and <strong>scalable performance<\/strong> from laboratory development to pilot and commercial manufacturing<\/li>\n<\/ul>\n\n\n\n<p>For companies implementing <strong>continuous bioprocessing<\/strong>, CaptureSMB provides an efficient path to <strong>industrial-scale continuous capture of monoclonal antibodies<\/strong> with reduced operating costs and increased facility throughput.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">About ChromaCon AG<\/h2>\n\n\n\n<p><strong>ChromaCon AG<\/strong> is a private Life Science Tools company headquartered in Zurich, Switzerland, specializing in <strong>continuous chromatography<\/strong> and <strong>process-intensified purification solutions<\/strong> for the biopharmaceutical industry. The company develops best-in-class <strong>process solutions, dynamic process control<\/strong> and <strong>process simulation tools<\/strong> for large-scale purification of biologics.<\/p>\n\n\n\n<p>ChromaCon has developed and patented novel <strong>continuous bioprocessing principles<\/strong> and advanced <strong>process control concepts<\/strong> that deliver significant CAPEX and OPEX savings. Its <strong>Contichrom\u00ae laboratory-scale systems<\/strong> are marketed worldwide by ChromaCon and its partners, enabling efficient development of continuous capture and polishing processes.<\/p>\n\n\n\n<p>ChromaCon has granted global licenses for its continuous process technologies to <strong>LEWA<\/strong> for implementation in <strong>EcoPrime\u00ae Twin<\/strong> scale-up systems, supporting a straightforward transition from lab to manufacturing scale.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">ChromaCon Contact<\/h3>\n\n\n\n<p>To find out more about ChromaCon\u2019s <strong>CaptureSMB continuous chromatography technology<\/strong> and <strong>Contichrom solutions<\/strong>, please contact:<\/p>\n\n\n\n<p><strong>Thomas M\u00fcller-Sp\u00e4th<\/strong><br> <a href=\"mailto:info@chromacon.com\">info@chromacon.com<\/a><br> <a href=\"https:\/\/www.chromacon.com\" target=\"_blank\" rel=\"noopener\">www.chromacon.com<\/a><\/p>\n\n\n<section id=\"block_7a210059753dea156ef45797c44d7ed3\" class=\"block-faq py-fluid-4xl alignfull  \"><div class=\"l-wrap\">\n            <div class=\"block-faq__header mb-fluid-m md:mb-fluid-3xl typo-off\">\n                            <h2 class=\"text-display-m leading-display-m leading-h1 md:text-h1 text-primary-800 text-center mb-fluid-xs\">Frequently Asked Questions About CaptureSMB\u00ae Twin-Column Continuous Chromatography<\/h2>\n                                <\/div>\n    \n            <div class=\"block-faq__accordion js-block-faq-accordion flex flex-col gap-fluid-s\">\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-0\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-0-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-0-content\"\n                        aria-label=\"Toggle question: What is the CaptureSMB\u00ae twin-column periodic counter-current chromatography process for monoclonal antibody purification?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What is the CaptureSMB\u00ae twin-column periodic counter-current chromatography process for monoclonal antibody purification?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-0-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-0-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>CaptureSMB\u00ae is ChromaCon\u2019s twin-column periodic counter-current Protein A capture technology designed for continuous monoclonal antibody (mAb) purification. Instead of using a single batch column, two columns are operated in a coordinated, semi-counter-current mode. While one column is loaded close to its dynamic binding capacity, the second column performs washing, elution, and regeneration. This configuration increases resin utilization, enables higher loading, and delivers significantly higher productivity for mAb capture compared with conventional single-column batch Protein A chromatography.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-1\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-1-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-1-content\"\n                        aria-label=\"Toggle question: How was CaptureSMB scaled from Contichrom\u00ae CUBE lab systems to Contichrom\u00ae TWIN industrial systems?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How was CaptureSMB scaled from Contichrom\u00ae CUBE lab systems to Contichrom\u00ae TWIN industrial systems?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-1-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-1-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>The CaptureSMB process was developed at laboratory scale on ChromaCon\u2019s Contichrom\u00ae CUBE system in Zurich and then transferred to a 100-fold larger Contichrom\u00ae TWIN system engineered by LEWA in Devens, MA. A joint team from Bristol-Myers Squibb, ChromaCon, and LEWA demonstrated that performance data from the small-scale CaptureSMB runs accurately predicted behavior at pilot and production scale. This one-to-one translation of key process parameters confirmed a robust and seamless scale-up strategy from development to industrial manufacturing for continuous Protein A capture.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-2\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-2-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-2-content\"\n                        aria-label=\"Toggle question: What are the main productivity and cost benefits of CaptureSMB vs. single-column batch Protein A capture?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What are the main productivity and cost benefits of CaptureSMB vs. single-column batch Protein A capture?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-2-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-2-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>In the reported scale-up study, the industrial CaptureSMB twin-column process delivered around 2.5-fold higher productivity compared with conventional single-column batch Protein A capture, measured as grams of mAb produced per liter of resin per hour. Resin utilization improved from approximately 67% to 92%, maximizing the value and lifetime of expensive chromatography media. In addition, buffer consumption was reduced by about 50%, which directly lowers operating costs, buffer storage requirements, and overall facility footprint. Together, these gains help reduce cost of goods (COGS) and increase facility throughput in commercial monoclonal antibody manufacturing.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-3\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-3-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-3-content\"\n                        aria-label=\"Toggle question: Is the twin-column CaptureSMB process suitable for GMP manufacturing and regulatory validation?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Is the twin-column CaptureSMB process suitable for GMP manufacturing and regulatory validation?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-3-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-3-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Yes. A key advantage of CaptureSMB is its simple twin-column architecture, which is easier to understand, validate, and document than more complex multi-column systems. According to ChromaCon\u2019s COO Thomas M\u00fcller-Sp\u00e4th, the low process complexity and predictable scale-up are important factors for process validation and regulatory approval. The successful industrial demonstration on the Contichrom\u00ae TWIN platform, combined with the use of well-established Protein A resins and hardware, positions CaptureSMB as a practical solution for GMP-compliant continuous downstream processing of therapeutic monoclonal antibodies.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-4\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-4-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-4-content\"\n                        aria-label=\"Toggle question: How can biopharmaceutical companies implement CaptureSMB continuous chromatography at industrial scale?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How can biopharmaceutical companies implement CaptureSMB continuous chromatography at industrial scale?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-4-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-4-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Biopharmaceutical manufacturers can start with process development on Contichrom\u00ae laboratory-scale systems from ChromaCon to optimize CaptureSMB conditions for their specific monoclonal antibody. The same process principles can then be transferred directly to LEWA\u2019s EcoPrime\u00ae Twin and Contichrom\u00ae TWIN systems for pilot and commercial-scale manufacturing. ChromaCon provides process know-how, dynamic control strategies, and simulation tools, while licensed partners such as LEWA supply industrial hardware. Together they offer an integrated path from lab development to validated GMP production, enabling fast adoption of continuous downstream processing and twin-column Protein A capture.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-5\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-5-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-5-content\"\n                        aria-label=\"Toggle question: What makes CaptureSMB an attractive option for companies adopting continuous bioprocessing?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What makes CaptureSMB an attractive option for companies adopting continuous bioprocessing?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-5-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_7a210059753dea156ef45797c44d7ed3-5-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>CaptureSMB combines the advantages of continuous chromatography with a straightforward two-column setup. For companies implementing continuous bioprocessing, it offers higher productivity, improved resin utilization, reduced buffer usage, and a scalable platform from lab to full-scale manufacturing. These features support lower operating costs, increased facility throughput, and a smoother regulatory path compared with more complex multi-column systems. As demonstrated in collaboration with Bristol-Myers Squibb and LEWA, CaptureSMB provides a proven, industry-ready solution for industrial-scale continuous capture of monoclonal antibodies.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                    <\/div>\n    \n<\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>A joint team from Bristol-Myers Squibb, ChromaCon and LEWA reports successful scale-up of the CaptureSMB continuous chromatography process for mAb purification. The 100-fold scale-up delivered 2.5\u00d7 higher productivity and 50% reduced buffer consumption compared to conventional batch capture.<\/p>\n","protected":false},"author":2,"featured_media":1426,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"categories":[159],"tags":[31,12],"class_list":["post-1422","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-news-events-cat","tag-scaleup","tag-capturesmb"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/comments?post=1422"}],"version-history":[{"count":6,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1422\/revisions"}],"predecessor-version":[{"id":3232,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1422\/revisions\/3232"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media\/1426"}],"wp:attachment":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media?parent=1422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/categories?post=1422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/tags?post=1422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}