{"id":1352,"date":"2020-07-16T18:06:00","date_gmt":"2020-07-16T18:06:00","guid":{"rendered":"https:\/\/www.chromacon.com\/?p=1352"},"modified":"2026-04-26T20:27:09","modified_gmt":"2026-04-26T18:27:09","slug":"fda-selects-ymc-twin-column-continuous-chromatography-system-for-evaluation","status":"publish","type":"post","link":"https:\/\/www.chromacon.com\/en\/news\/fda-selects-ymc-twin-column-continuous-chromatography-system-for-evaluation\/","title":{"rendered":"FDA Selects YMC Twin-Column Continuous Chromatography System for Evaluation"},"content":{"rendered":"\n<p><strong>Devens, MA, USA \/ Zurich, Switzerland \u2013 July 2020<\/strong> \u2013 The U.S. Food and Drug Administration (FDA) has selected the <strong>YMC Contichrom<sup>\u00ae<\/sup> CUBE<\/strong>, a twin-column continuous chromatography system from <strong>YMC ChromaCon<\/strong>, to evaluate advanced continuous purification strategies for biopharmaceutical manufacturing.<\/p>\n\n\n\n<p>The FDA\u2019s acquisition of the Contichrom CUBE underscores growing industry and regulatory interest in <strong>continuous chromatography<\/strong> to reduce costs, increase productivity, and maintain high product quality for both small and large molecule therapeutics.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Continuous Twin-Column Chromatography Platform Chosen by FDA<\/h2>\n\n\n\n<p>The FDA has ordered a development-scale <strong>YMC Contichrom CUBE<\/strong> system equipped with YMC\u2019s patented twin-column processes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MCSGP<\/strong><em> \u2013 Multi-Column Countercurrent Solvent Gradient Purification for semi-continuous gradient separations of peptides, oligos and other complex molecules.<\/em><\/li>\n\n\n\n<li><strong>CaptureSMB<\/strong> \u2013 Twin-column continuous capture chromatography for mAbs and other biologics.<\/li>\n<\/ul>\n\n\n\n<p>The bench-top unit also includes <strong>AutoPeak<\/strong> and <strong>AutoMab<\/strong> dynamic process control software and is capable of:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Conventional single-column batch chromatography<\/li>\n\n\n\n<li>Sequential orthogonal (pool-less two-step polishing) chromatography<\/li>\n\n\n\n<li>Unique N-Rich processing for challenging separations<\/li>\n<\/ul>\n\n\n\n<p>MCSGP = multi-column countercurrent solvent gradient purification.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Proven Performance for Biologics and Advanced Therapies<\/h2>\n\n\n\n<p>The Contichrom CUBE platform embodies YMC\u2019s intellectual property for twin-column continuous chromatography, already implemented at numerous GMP producers of <strong>monoclonal antibodies (mAbs)<\/strong>, <strong>vaccines<\/strong>, <strong>peptides<\/strong>, <strong>oligonucleotides<\/strong> and other advanced biotherapeutics in the USA, Europe and Asia.<\/p>\n\n\n\n<p>Users report significant performance advantages when applying YMC\u2019s patented processes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MCSGP for peptides and oligos:<\/strong> 30\u201360% gains in product yield while reducing solvent consumption by up to 70%, thanks to automated internal recycling of impure side fractions.<\/li>\n\n\n\n<li><strong>CaptureSMB for mAb-based therapies:<\/strong> Scaled from CUBE to production processes exceeding 20 L\/min, with reductions in Protein A resin and buffer consumption by up to 60% and productivity increases of up to 3\u00d7 versus conventional single-column batch capture.<\/li>\n<\/ul>\n\n\n\n<p>These gains are achieved while maintaining the high product purity demanded for clinical and commercial biopharmaceutical production.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Supporting the Transition to Continuous Bioprocessing<\/h2>\n\n\n\n<p>The FDA has long encouraged the adoption of <strong>continuous processing<\/strong> across the pharmaceutical and biopharmaceutical industries. With the YMC Contichrom CUBE, FDA scientists and academic collaborators will be able to generate additional data, case studies and best practices to support broader implementation of continuous chromatographic processes.<\/p>\n\n\n\n<p><em>\u201cThe acquisition of YMC\u2019s twin-column technology by the FDA is welcome and signals that this emerging technology will be evaluated by the world\u2019s leading regulatory authority for its ability to significantly reduce costs through improved process efficiency, while maintaining product quality,\u201d<\/em> says <strong>Mark Dyment<\/strong>, CEO of YMC Process Technologies, the USA-based supplier of the Contichrom CUBE instrument.<\/p>\n\n\n\n<p><em>\u201cThe scalable technology, patented by YMC ChromaCon and already in use by many of the industry\u2019s largest drug manufacturers, in the hands of the FDA will add further insights on continuous chromatographic processes for customers seeking to produce new therapies at cost-effective quantities.\u201d<\/em><\/p>\n\n\n\n<p>The Contichrom CUBE units are manufactured in the USA and will be finally assembled at <strong>YMC\u2019s Center of Excellence for GMP scale in Devens, Massachusetts<\/strong>, before shipment to the FDA\u2019s laboratories in Maryland.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Key Benefits of YMC Twin-Column Continuous Chromatography<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Higher yield:<\/strong> Automated internal recycling recovers valuable product from overlapping peak regions that are typically discarded in batch chromatography.<\/li>\n\n\n\n<li><strong>Lower solvent and buffer usage:<\/strong> MCSGP and CaptureSMB can significantly reduce solvent and buffer consumption, lowering overall cost of goods.<\/li>\n\n\n\n<li><strong>Increased productivity:<\/strong> Continuous operation and higher effective loading lead to throughput gains of up to several-fold compared with single-column batch processes.<\/li>\n\n\n\n<li><strong>Scalable from lab to GMP:<\/strong> Processes developed on the Contichrom CUBE can be scaled to clinical and commercial production using YMC\u2019s GMP-scale systems.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">About YMC<\/h2>\n\n\n\n<p><strong>YMC Co., Ltd.<\/strong> is a privately held life science company headquartered in Kyoto, Japan. Founded in 1980, YMC operates more than nine affiliates and facilities across Asia, Europe and the Americas, employing over 500 people dedicated to providing best-in-class laboratory and process solutions to the bio\/pharmaceutical industry.<\/p>\n\n\n\n<p>YMC\u2019s core expertise includes the innovation, production and sale of packing materials, packed columns and systems for <strong>high performance liquid chromatography (HPLC)<\/strong>, <strong>low pressure liquid chromatography (LPLC)<\/strong>, and custom purification and synthesis. The company operates a contract manufacturing (CMO) facility and recently opened \u201cKyoto Works,\u201d a state-of-the-art lab and pilot site focused on multi-column purification and process scale-up.<\/p>\n\n\n\n<p><strong>YMC Process Technologies (YPT)<\/strong> in Devens, MA, USA has supplied GMP-scale downstream process systems for nearly 20 years. Acquired by YMC in 2018, the YPT Bio\/Pharma Systems Group, together with its sister affiliate <strong>YMC ChromaCon<\/strong> in Zurich, is a leading provider of lab and production-scale single- and multi-column chromatography systems. YMC\u2019s intellectual assets and deep application know-how support the purification and discovery of next-generation small and large molecule therapies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Media Contact<\/h2>\n\n\n\n<p>For additional information about this press release and YMC twin-column continuous chromatography solutions, please contact:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Dr. Thomas M\u00fcller-Sp\u00e4th<\/strong>, Director R&amp;D, YMC ChromaCon AG \u2013 <a href=\"mailto:info@chromacon.com\">info@chromacon.com<\/a> \u2013 <a href=\"https:\/\/www.chromacon.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">www.chromacon.com<\/a><\/li>\n<\/ul>\n\n\n\n<p><em>YMC is a registered trademark of YMC Co., Ltd. Contichrom is a registered trademark of YMC ChromaCon AG.<\/em><\/p>\n\n\n<section id=\"block_9283535c2b3ed233f6cc15de23a40353\" class=\"block-faq py-fluid-4xl alignfull  \"><div class=\"l-wrap\">\n            <div class=\"block-faq__header mb-fluid-m md:mb-fluid-3xl typo-off\">\n                            <h2 class=\"text-display-m leading-display-m leading-h1 md:text-h1 text-primary-800 text-center mb-fluid-xs\">Frequently Asked Questions About YMC Contichrom\u00ae CUBE and FDA Continuous Chromatography Evaluation<\/h2>\n                                <\/div>\n    \n            <div class=\"block-faq__accordion js-block-faq-accordion flex flex-col gap-fluid-s\">\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-0\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-0-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-0-content\"\n                        aria-label=\"Toggle question: What is the YMC Contichrom\u00ae CUBE, and why did the FDA select it?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What is the YMC Contichrom\u00ae CUBE, and why did the FDA select it?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-0-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-0-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>The YMC Contichrom\u00ae CUBE is a development-scale, twin-column continuous chromatography system designed for advanced purification of biopharmaceuticals. The U.S. Food and Drug Administration (FDA) selected the Contichrom CUBE to evaluate next-generation continuous chromatography strategies because it combines YMC\u2019s patented MCSGP and CaptureSMB processes with dynamic control software, enabling higher yield, lower solvent and resin consumption, and increased productivity for biologics and advanced therapies.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-1\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-1-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-1-content\"\n                        aria-label=\"Toggle question: How do MCSGP and CaptureSMB on the Contichrom CUBE improve biopharmaceutical purification?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How do MCSGP and CaptureSMB on the Contichrom CUBE improve biopharmaceutical purification?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-1-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-1-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>MCSGP (Multi-Column Countercurrent Solvent Gradient Purification) enables semi-continuous gradient separations for peptides, oligonucleotides and other complex molecules, delivering 30\u201360% yield gains while cutting solvent use by up to 70% through automated internal recycling of impure side fractions. CaptureSMB is a twin-column continuous capture process for monoclonal antibodies (mAbs) and other biologics that can reduce Protein A resin and buffer consumption by up to 60% and boost productivity up to 3\u00d7 compared with conventional single-column batch capture.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-2\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-2-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-2-content\"\n                        aria-label=\"Toggle question: Which molecules and modalities can be processed on the YMC twin-column continuous chromatography platform?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Which molecules and modalities can be processed on the YMC twin-column continuous chromatography platform?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-2-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-2-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>The YMC Contichrom CUBE and related twin-column systems are used for a wide range of biotherapeutics, including monoclonal antibodies (mAbs), vaccines, peptides, oligonucleotides and other advanced biologics. GMP producers in the USA, Europe and Asia deploy YMC\u2019s multi-column continuous chromatography technology to purify both small and large molecule therapies at laboratory, clinical and commercial manufacturing scale.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-3\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-3-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-3-content\"\n                        aria-label=\"Toggle question: How does the Contichrom CUBE support the transition from batch to continuous bioprocessing and GMP scale-up?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How does the Contichrom CUBE support the transition from batch to continuous bioprocessing and GMP scale-up?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-3-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-3-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>The Contichrom CUBE bench-top unit can run conventional single-column batch chromatography, sequential orthogonal (pool-less two-step polishing) chromatography, and twin-column continuous modes such as MCSGP and CaptureSMB on the same platform. Processes developed on the CUBE can be scaled directly to YMC\u2019s GMP-scale systems, enabling a smooth transition from R&amp;D to clinical and commercial continuous bioprocessing while maintaining the high product purity required for regulatory approval.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-4\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-4-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-4-content\"\n                        aria-label=\"Toggle question: What are the key economic and sustainability benefits of YMC twin-column continuous chromatography?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What are the key economic and sustainability benefits of YMC twin-column continuous chromatography?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-4-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9283535c2b3ed233f6cc15de23a40353-4-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>YMC\u2019s twin-column continuous chromatography significantly improves process economics by increasing product yield, cutting solvent and buffer consumption, and boosting throughput. Automated internal recycling of overlapping peak regions recovers valuable product that is typically discarded in batch chromatography, while reduced use of Protein A resin and process buffers lowers cost of goods and waste volumes. These advantages support more sustainable, cost-effective biopharmaceutical manufacturing for next-generation therapies.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                    <\/div>\n    \n<\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>The U.S. FDA has selected the YMC Contichrom\u00ae CUBE twin-column continuous chromatography system to evaluate advanced purification strategies for biopharmaceutical manufacturing. This acquisition signals growing regulatory interest in continuous chromatography to reduce costs and increase productivity.<\/p>\n","protected":false},"author":2,"featured_media":1436,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"categories":[159],"tags":[28,25],"class_list":["post-1352","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-news-events-cat","tag-cube-purchase","tag-fda"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/comments?post=1352"}],"version-history":[{"count":8,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1352\/revisions"}],"predecessor-version":[{"id":3227,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/1352\/revisions\/3227"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media\/1436"}],"wp:attachment":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media?parent=1352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/categories?post=1352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/tags?post=1352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}