{"id":12775,"date":"2026-06-10T14:51:03","date_gmt":"2026-06-10T12:51:03","guid":{"rendered":"https:\/\/www.chromacon.com\/?p=12775"},"modified":"2026-06-10T14:51:03","modified_gmt":"2026-06-10T12:51:03","slug":"besig-bioprocessing-2026-ucl","status":"publish","type":"post","link":"https:\/\/www.chromacon.com\/en\/news\/besig-bioprocessing-2026-ucl\/","title":{"rendered":"YMC ChromaCon at the BESIG Novel Technologies in Bioprocessing Conference \u2014 UCL, London, 23 June"},"content":{"rendered":"\n<p class=\"is-style-default has-text-l-font-size wp-block-paragraph\"><em><em>A one-day IChemE BESIG conference on the newest developments in bioprocessing tools and strategies. Our CEO presents continuous chromatography for biologics \u2014 capture and polishing for monoclonal antibodies, bispecifics, and ADCs.<\/em><\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Event at a Glance<\/h2>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Event<\/strong><\/td><td>BESIG Novel Technologies in Bioprocessing Conference (IChemE Biochemical Engineering Special Interest Group)<\/td><\/tr><tr><td><strong>Date<\/strong><\/td><td>Tuesday, 23 June 2026 (one-day conference)<\/td><\/tr><tr><td><strong>Venue<\/strong><\/td><td>University College London (UCL), London, United Kingdom<\/td><\/tr><tr><td><strong>YMC ChromaCon focus<\/strong><\/td><td>Continuous chromatography for biologics \u2014 CaptureSMB\u00ae capture and MCSGP polishing for mAbs, bispecifics, and ADCs<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Our Talk<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Continuous Chromatography for Biologics<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tuesday, 23 June 2026<\/strong> \u00b7 UCL, London<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Dr. Thomas M\u00fcller-Sp\u00e4th<\/strong> \u2014 CEO and co-founder, ChromaCon AG, a YMC company<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Continuous chromatography offers tremendous improvements in throughput and cost for the downstream processing of biologics. This presentation introduces the core principles of continuous chromatography, then works through case studies across monoclonal antibodies, bispecific antibodies, and antibody-drug conjugates (ADCs). It also covers the two factors that determine whether a continuous process is genuinely production-ready: dynamic process control and scale-up.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The talk addresses, in turn:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Continuous capture for monoclonal antibodies. <\/strong>CaptureSMB\u00ae twin-column periodic countercurrent capture loads Protein A resin safely beyond breakthrough, delivering 2.5\u00d7 higher productivity, 92% resin utilisation, and 50% buffer savings versus batch \u2014 validated from lab to GMP scale by Bristol Myers Squibb. AutomAb\u00ae dynamic control adjusts loading duration in real time to compensate for feed titer variability and column aging.<\/li>\n\n\n\n<li><strong>Polishing for bispecifics and ADCs. <\/strong>MCSGP continuous polishing eliminates the purity-yield trade-off of batch chromatography by internally recycling impure side-fractions. For bispecific charge-variant profiles and high-value ADC payloads, AutoPeak\u00ae dynamic control keeps the product collection window precisely on target across long campaigns.<\/li>\n\n\n\n<li><strong>Process control and scale-up. <\/strong>AutomAb\u00ae and AutoPeak\u00ae \u2014 our proprietary UV-based dynamic control technologies \u2014 are what take a continuous process from development-ready to production-ready, and are validated as Process Analytical Technology (PAT). Methods transfer directly from the Contichrom\u00ae CUBE to GMP manufacturing on the Contichrom\u00ae TWIN.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Case Studies at a Glance<\/h2>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>Antibody format<\/strong><\/td><td><strong>Continuous chromatography approach<\/strong><\/td><td><strong>What it delivers<\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Monoclonal antibodies<\/strong><\/td><td>Continuous Protein A capture with CaptureSMB\u00ae and AutomAb\u00ae dynamic control<\/td><td>2.5\u00d7 higher productivity, 92% resin utilisation, 50% less buffer \u2014 validated lab-to-GMP by Bristol Myers Squibb<\/td><\/tr><tr><td><strong>Bispecific antibodies<\/strong><\/td><td>MCSGP continuous polishing with AutoPeak\u00ae dynamic control<\/td><td>Resolves complex charge-variant profiles with tight, UV-tracked collection windows<\/td><\/tr><tr><td><strong>ADCs<\/strong><\/td><td>MCSGP continuous polishing of payloads and conjugates<\/td><td>Recovers high-value product that batch polishing discards; reduces in-process controls and PMI<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Meet Us at UCL<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Thomas M\u00fcller-Sp\u00e4th and the YMC ChromaCon team will be available during the conference to discuss:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Continuous Protein A capture (<strong>CaptureSMB\u00ae<\/strong>) for mAbs, bispecifics, Fc-fusion proteins, and antibody fragments<\/li>\n\n\n\n<li>Continuous polishing (<strong>MCSGP<\/strong>) for charge variants, aggregates, and ADC payloads<\/li>\n\n\n\n<li>Dynamic process control with <strong>AutomAb\u00ae<\/strong> and <strong>AutoPeak\u00ae<\/strong> \u2014 validated as PAT<\/li>\n\n\n\n<li>Process development on the <strong>Contichrom\u00ae CUBE<\/strong> and scale-up to GMP manufacturing on the <strong>Contichrom\u00ae TWIN<\/strong><\/li>\n\n\n\n<li>Integration of continuous capture with perfusion bioreactors for end-to-end continuous biomanufacturing<\/li>\n\n\n\n<li>Feasibility studies, rental options, and on-site demos at our Zurich facility<\/li>\n<\/ul>\n\n\n<div id=\"block_388b8add367c66f9eb4e1242c9b67bf0\" class=\"block-button-advanced default-block-spacing text-center typo-off  \">\n            <span class=\"c-btn-focus-wrapper\"><a href=\"https:\/\/www.chromacon.com\/en\/contact\/\" class=\"c-btn c-btn--regular c-btn--primary c-btn--light\"><span>Request a Meeting<\/span><\/a><\/span>    \n    <\/div> \n\n\n<h2 class=\"wp-block-heading\">About the Speaker<\/h2>\n\n\n\n<p class=\"is-style-default has-text-l-font-size wp-block-paragraph\"><strong>Dr. Thomas M\u00fcller-Sp\u00e4th<\/strong> is CEO and co-founder of ChromaCon AG, a YMC company, and an expert in downstream processing and continuous bioprocessing technologies, with extensive experience in chromatography process development, scale-up, and manufacturing for biologics. He has led the development of CaptureSMB\u00ae, MCSGP, AutomAb\u00ae, AutoPeak\u00ae, and N-Rich\u00ae from research concept to GMP-validated commercial technology.<\/p>\n\n\n<section id=\"block_9e6071ae52e2c9016d580b7801104ce2\" class=\"block-faq py-fluid-4xl alignfull  \"><div class=\"l-wrap\">\n            <div class=\"block-faq__header mb-fluid-m md:mb-fluid-3xl typo-off\">\n                            <h2 class=\"text-display-m leading-display-m leading-h1 md:text-h1 text-primary-800 text-center mb-fluid-xs\">Frequently Asked Questions<\/h2>\n                                <\/div>\n    \n            <div class=\"block-faq__accordion js-block-faq-accordion flex flex-col gap-fluid-s\">\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-0\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-0-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-0-content\"\n                        aria-label=\"Toggle question: What is YMC ChromaCon presenting at the BESIG conference?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What is YMC ChromaCon presenting at the BESIG conference?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-0-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-0-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Dr. Thomas M\u00fcller-Sp\u00e4th, CEO and co-founder of ChromaCon AG (a YMC company), will present \u201cContinuous Chromatography for Biologics\u201d at the BESIG Novel Technologies in Bioprocessing Conference at UCL on 23 June 2026. The talk introduces continuous chromatography principles, then works through case studies on monoclonal antibodies, bispecific antibodies, and ADCs, plus process control and scale-up.<\/p>\n<p>&nbsp;<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-1\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-1-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-1-content\"\n                        aria-label=\"Toggle question: How does CaptureSMB\u00ae improve monoclonal antibody capture?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How does CaptureSMB\u00ae improve monoclonal antibody capture?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-1-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-1-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Conventional batch Protein A capture loads resin conservatively to only 50\u201370% of its dynamic binding capacity to avoid product breakthrough, leaving expensive resin underused. CaptureSMB\u00ae uses two columns in periodic countercurrent mode so the second column captures any breakthrough, allowing the first to be loaded safely beyond breakthrough. Bristol Myers Squibb validated 2.5\u00d7 higher productivity, 92% resin utilization, and 50% buffer savings, with equivalent yield and viral clearance, from lab to GMP scale.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-2\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-2-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-2-content\"\n                        aria-label=\"Toggle question: How is continuous chromatography relevant to bispecifics and ADCs?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How is continuous chromatography relevant to bispecifics and ADCs?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-2-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-2-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Bispecific antibodies carry complex charge-variant and homodimer profiles that demand high-resolution polishing; ADC payloads and conjugates are among the most expensive molecules in manufacturing, so product recovery is critical. MCSGP continuous polishing internally recycles impure side-fractions, recovering product that batch chromatography discards while holding target purity. AutoPeak\u00ae dynamic control keeps the collection window precisely on target across long campaigns.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-3\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-3-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-3-content\"\n                        aria-label=\"Toggle question: What are AutomAb\u00ae and AutoPeak\u00ae?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">What are AutomAb\u00ae and AutoPeak\u00ae?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-3-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-3-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>They are YMC ChromaCon&#8217;s proprietary UV-based dynamic process control technologies. AutomAb\u00ae controls the loading phase in CaptureSMB\u00ae capture, adjusting loading duration in real time from the breakthrough curve to compensate for feed titer variability and column aging. AutoPeak\u00ae controls the collection window in MCSGP polishing, tracking the elution profile to compensate for retention time drift. Both are validated as Process Analytical Technology (PAT) and are what make a continuous process production-ready.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-4\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-4-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-4-content\"\n                        aria-label=\"Toggle question: Has continuous chromatography been validated at production scale?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Has continuous chromatography been validated at production scale?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-4-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-4-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Yes. Bristol Myers Squibb validated CaptureSMB\u00ae continuous capture from lab to GMP production scale with 100\u00d7 scale-up, demonstrating consistent yield, comparable product quality, and equivalent viral clearance (published in BioProcess International, 2018, and Biotechnology and Bioengineering, 2019 and 2021). MCSGP continuous polishing has been GMP-validated for peptide manufacturing at Bachem since 2022, with a published Process Characterization and Performance Qualification framework (Eisenhuth &amp; M\u00fcller-Sp\u00e4th, <em>Processes<\/em>, 2025).<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-5\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-5-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-5-content\"\n                        aria-label=\"Toggle question: Can one system run both capture and polishing, and does it scale?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">Can one system run both capture and polishing, and does it scale?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-5-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-5-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Yes. All Contichrom\u00ae systems run CaptureSMB\u00ae continuous capture, MCSGP continuous polishing, batch, and 2D\/3D integrated batch on the same hardware. Processes are developed on the lab-scale Contichrom\u00ae CUBE and transfer directly to the Contichrom\u00ae TWIN for GMP manufacturing, with control setpoints carrying over without re-optimization.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                            <div\n                    class=\"block-faq__item bg-white px-[14px] py-[24px] md:py-fluid-m md:px-fluid-l\"\n                    id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-6\"\n                    data-faq-item>\n                    <button \n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-6-trigger\"\n                        class=\"block-faq__trigger appearance-none flex items-center justify-between cursor-pointer select-none w-full text-left\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-6-content\"\n                        aria-label=\"Toggle question: How can I meet the YMC ChromaCon at the conference?\">\n                        <h3 class=\"!text-h4 md:!m-fluid-2xs text-primary-800 flex-1\">How can I meet the YMC ChromaCon at the conference?<\/h3>\n\n                        <div class=\"block-faq__icon-wrapper relative shrink-0 ml-4 w-5 h-5\" aria-hidden=\"true\">\n                            <span class=\"block-faq__icon block-faq__icon--plus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-100\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M256 80c0-17.7-14.3-32-32-32s-32 14.3-32 32l0 144L48 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l144 0 0 144c0 17.7 14.3 32 32 32s32-14.3 32-32l0-144 144 0c17.7 0 32-14.3 32-32s-14.3-32-32-32l-144 0 0-144z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                            <span class=\"block-faq__icon block-faq__icon--minus absolute top-0 left-0 w-full h-full flex items-center justify-center transition-opacity duration-300 ease-in-out opacity-0\">\n                                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa w-5 h-5\" role=\"img\" aria-hidden=\"true\" style=\"color:currentColor\"><!--! Font Awesome Free 6.7.2 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) Copyright 2024 Fonticons, Inc. --><path d=\"M432 256c0 17.7-14.3 32-32 32L48 288c-17.7 0-32-14.3-32-32s14.3-32 32-32l352 0c17.7 0 32 14.3 32 32z\" fill=\"currentColor\"><\/path><\/svg>\n                            <\/span>\n                        <\/div>\n                    <\/button>\n\n                    <div \n                        class=\"block-faq__content-wrapper overflow-hidden h-0\"\n                        id=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-6-content\"\n                        role=\"region\"\n                        aria-labelledby=\"faq-item-block_9e6071ae52e2c9016d580b7801104ce2-6-trigger\"\n                        aria-hidden=\"true\">\n                        <div class=\"block-faq__content pb-1 md:pt-fluid-2xs md:px-fluid-s overflow-y-clip opacity-0 transition-opacity duration-[400ms] ease-in-out\">\n                            <p>Dr. Thomas M\u00fcller-Sp\u00e4th will be at UCL on 23 June 2026. Use the contact form to arrange a meeting. We can discuss CaptureSMB\u00ae and MCSGP for your specific biologic, dynamic process control, perfusion integration, feasibility studies at our Zurich facility, Contichrom\u00ae CUBE rental, or scale-up to the Contichrom\u00ae TWIN.<\/p>\n                            \n                                                                                <\/div>\n                    <\/div>\n                <\/div>\n                    <\/div>\n    \n<\/div><\/section>","protected":false},"excerpt":{"rendered":"<p>YMC ChromaCon&#8217;s Dr. Thomas M\u00fcller-Sp\u00e4th presents &#8220;Continuous Chromatography for Biologics&#8221; at the IChemE BESIG conference at UCL on 23 June 2026 \u2014 capture and polishing case studies across monoclonal antibodies, bispecifics, and ADCs, plus process control and scale-up.<\/p>\n","protected":false},"author":2,"featured_media":12788,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"Continuous Chromatography for Biologics | BESIG, UCL 2026","_seopress_titles_desc":"Meet YMC ChromaCon at BESIG Novel Technologies in Bioprocessing, UCL, 23 June 2026. Continuous capture and polishing for mAbs, bispecifics and ADCs. CaptureSMB\u00ae & MCSGP.","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"288","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"footnotes":""},"categories":[288],"tags":[293],"class_list":["post-12775","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-events","tag-besig-conference"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/12775","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/comments?post=12775"}],"version-history":[{"count":5,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/12775\/revisions"}],"predecessor-version":[{"id":12784,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/posts\/12775\/revisions\/12784"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media\/12788"}],"wp:attachment":[{"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/media?parent=12775"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/categories?post=12775"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.chromacon.com\/en\/wp-json\/wp\/v2\/tags?post=12775"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}