{"id":3615,"date":"2026-02-06T12:18:17","date_gmt":"2026-02-06T11:18:17","guid":{"rendered":"https:\/\/www.chromacon.com\/?page_id=3615"},"modified":"2026-05-10T16:39:59","modified_gmt":"2026-05-10T14:39:59","slug":"technologies","status":"publish","type":"page","link":"https:\/\/www.chromacon.com\/en\/technologies\/","title":{"rendered":"Technologies Overview"},"content":{"rendered":"
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\n TECHNOLOGIES <\/p>\n \n

\n Contichrom\u00ae<\/strong> – Continuous Chromatography Technologies\n <\/h1>\n \n
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Five process modes, one hardware platform. Run batch, integrated 2D\/3D batch, or fully continuous chromatography (MCSGP, CaptureSMB\u00ae, N-Rich\u00ae) on the same Contichrom\u00ae system \u2014 with the same resins, the same buffers, and a single ChromIQ\u00ae software environment.<\/p>\n <\/div>\n <\/div>\n\n

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\n Request a Webinar<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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\n Request a Webinar<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n\n
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\n Advanced Chromatography for Every Purification Challenge <\/h2>\n \n
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One platform, five process modes. The Contichrom\u00ae system runs batch, multi-dimensional (2D\/3D), and twin-column continuous chromatography \u2014 so you can match the right technology to every molecule and every stage of development.<\/p>\n

Higher yield, lower cost.<\/strong> Continuous processes like MCSGP resolve the purity-yield trade-off, reduce solvent and buffer consumption, and enable 24\/7 automated manufacturing \u2014 significantly lowering cost of goods.<\/p>\n

Select a technology below to learn how it works, see application data, and find the right Contichrom\u00ae system for your process.<\/p>\n <\/div>\n \n <\/div>\n\n

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Choose a Technology<\/p>\n <\/h2>\n

\n Five process modes, one hardware platform. <\/p>\n <\/div>\n \n

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\n \"Batch <\/div>\n \n \n
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\n Batch Chromatography<\/span>\n

Single-column purification with full method flexibility \u2014 gradient, isocratic, step elution. The foundation for process development and the starting point for continuous workflows.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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Single-column purification with full method flexibility \u2014 gradient, isocratic, step elution. The foundation for process development and the starting point for continuous workflows.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n \n \n \n

\n \"Multi-Dimensional <\/div>\n \n \n
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\n Multi-Dimensional Chromatography (2D\/3D)<\/span>\n

Automate sequential purification across multiple columns and chemistries in a single run. ChromIQ\u00ae handles fraction transfer, timing, and method switching.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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Automate sequential purification across multiple columns and chemistries in a single run. ChromIQ\u00ae handles fraction transfer, timing, and method switching.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n \n \n \n

\n \"Continuous <\/div>\n \n \n
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\n Continuous Capture (CaptureSMB\u00ae)<\/span>\n

Twin-column continuous loading maximizes resin utilization and throughput. AutomAb\u00ae dynamically controls breakthrough \u2014 adapting in real time to feed variability.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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Twin-column continuous loading maximizes resin utilization and throughput. AutomAb\u00ae dynamically controls breakthrough \u2014 adapting in real time to feed variability.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n \n \n \n

\n \"Continuous <\/div>\n \n \n
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\n Continuous Polishing (MCSGP)<\/span>\n

Overlapping fractions are automatically recycled between twin columns, breaking the yield\u2013purity tradeoff. AutoPeak\u00ae dynamic control maintains performance cycle to cycle.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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Overlapping fractions are automatically recycled between twin columns, breaking the yield\u2013purity tradeoff. AutoPeak\u00ae dynamic control maintains performance cycle to cycle.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n \n \n \n

\n \"Continuous <\/div>\n \n \n
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\n Continuous Enrichment (N-Rich\u00ae)<\/span>\n

Automated on-column enrichment of trace-level impurities from repeated injections. Replaces weeks of manual fraction pooling with a single unattended run.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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Automated on-column enrichment of trace-level impurities from repeated injections. Replaces weeks of manual fraction pooling with a single unattended run.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n \n \n \n

\n \"Dynamic <\/div>\n \n \n
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\n Dynamic Process Control (AutoPeak\u00ae & AutomAb\u00ae)<\/span>\n

Real-time UV-based control that adapts your continuous process to feed and column variability \u2014 eliminating the need for fixed, conservative operating parameters.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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Real-time UV-based control that adapts your continuous process to feed and column variability \u2014 eliminating the need for fixed, conservative operating parameters.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n <\/div>\n \n<\/div><\/section>\n\n

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Frequently Asked Questions<\/h2>\n <\/div>\n \n
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