{"id":2309,"date":"2025-12-12T00:34:25","date_gmt":"2025-12-12T00:34:25","guid":{"rendered":"https:\/\/www.chromacon.com\/?page_id=2309"},"modified":"2026-05-12T18:13:29","modified_gmt":"2026-05-12T16:13:29","slug":"homepage","status":"publish","type":"page","link":"https:\/\/www.chromacon.com\/en\/","title":{"rendered":"Homepage"},"content":{"rendered":"
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\n CONTINUOUS CHROMATOGRAPHY <\/p>\n \n

\n More Product. Fewer IPCs. MCSGP for Peptide & Oligo<\/strong> Manufacturing\n <\/h1>\n \n
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MCSGP + AutoPeak\u00ae<\/strong>: a twin-column preparative chromatography process with UV-based dynamic process control. Eliminates the purity\u2013yield trade-off in preparative HPLC for reversed-phase and AIEX polishing of peptides and oligonucleotides. AutoPeak\u00ae \u2014 essential for MCSGP manufacturing \u2014 available only on the Contichrom\u00ae platform<\/p>\n

Across 4 PPQ runs: 99.2%<\/strong> Purity | \u221296%<\/strong> In-process controls | \u221273%<\/strong> Process Mass Intensity | Multi-day<\/strong> unattended operation | +9%<\/strong> Yield gain<\/p>\n

Source: Eisenhuth & M\u00fcller-Sp\u00e4th, Processes 2025 (Bachem Bivalirudin PPQ campaign, Open Access)<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n <\/div>\n <\/div>\n\n

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\n Discuss Your Process<\/span><\/a><\/span> <\/div>\n
\n Download the PPQ Paper<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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\n \"Scientist <\/div>\n\n \n
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\n Discuss Your Process<\/span><\/a><\/span> <\/div>\n
\n Download the PPQ Paper<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n\n
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Find the Ideal Twin-Column<\/strong> Process for Your Application<\/p>\n <\/h2>\n

\n Whether you need MCSGP continuous polishing for peptides and oligonucleotides or CaptureSMB\u00ae continuous capture for mAbs and biologics, YMC ChromaCon’s Contichrom\u00ae systems deliver higher yield, lower cost, and consistent results from lab to production scale. <\/p>\n <\/div>\n \n

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\n \"Peptides\" <\/div>\n \n \n
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\n Peptides<\/span>\n

MCSGP with AutoPeak\u00ae achieves scalable, cost-effective purification for complex synthetic peptides, maximizing recovery by automatically recycling low purity side-cuts.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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MCSGP with AutoPeak\u00ae achieves scalable, cost-effective purification for complex synthetic peptides, maximizing recovery by automatically recycling low purity side-cuts.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n

\n \"Oligonucleotides\" <\/div>\n \n \n
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\n Oligonucleotides<\/span>\n

MCSGP with AutoPeak\u00ae breaks the yield-purity tradeoff delivering higher oligonucleotide yields without sacrificing purity. <\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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MCSGP with AutoPeak\u00ae breaks the yield-purity tradeoff delivering higher oligonucleotide yields without sacrificing purity. <\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n

\n \"mAbs <\/div>\n \n \n
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\n mAbs & Antibody Variants<\/span>\n

CaptureSMB\u00ae with AutomAb\u00ae for mAbs & antibody variants: maximize productivity and resin utilization, while slashing buffer consumption.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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CaptureSMB\u00ae with AutomAb\u00ae for mAbs & antibody variants: maximize productivity and resin utilization, while slashing buffer consumption.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n

\n \"Antibody-drug <\/div>\n \n \n
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\n Antibody-drug Conjugates<\/span>\n

MCSGP with AutoPeak\u00ae is ideally suited for DAR control, achieving precise drug-antibody ratios with higher yield than batch chromatography.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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MCSGP with AutoPeak\u00ae is ideally suited for DAR control, achieving precise drug-antibody ratios with higher yield than batch chromatography.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n

\n \"Recombinant <\/div>\n \n \n
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\n Recombinant Proteins<\/span>\n

From capture through polishing, Contichrom\u00ae integrates multiple chromatography steps into automated 2D\/3D workflows \u2014 reducing hands-on time and intermediate handling.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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From capture through polishing, Contichrom\u00ae integrates multiple chromatography steps into automated 2D\/3D workflows \u2014 reducing hands-on time and intermediate handling.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n

\n \"Viral <\/div>\n \n \n
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\n Viral Vectors (AAV)<\/span>\n

Continuous chromatography improves full\/empty capsid separation and recovery, supporting scalable AAV manufacturing.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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Continuous chromatography improves full\/empty capsid separation and recovery, supporting scalable AAV manufacturing.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n

\n \"Small <\/div>\n \n \n
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\n Small Molecules & Nutraceuticals<\/span>\n

High-pressure continuous chromatography on the Contichrom\u00ae platform enables efficient purification of natural compounds and small molecules at preparative scale. <\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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High-pressure continuous chromatography on the Contichrom\u00ae platform enables efficient purification of natural compounds and small molecules at preparative scale. <\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n \n

\n \"Impurity <\/div>\n \n \n
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\n Impurity Isolation<\/span>\n

N-Rich automates on-column enrichment of low-abundance impurities, replacing weeks of repetitive HPLC runs with a single automated process.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/div>\n\n \n

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N-Rich automates on-column enrichment of low-abundance impurities, replacing weeks of repetitive HPLC runs with a single automated process.<\/p>\n <\/div>\n <\/div>\n \n <\/path><\/svg>\n <\/span>\n <\/div>\n <\/a>\n <\/div>\n \n<\/div><\/section>\n\n
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\n \"\"\n\n Technologies Overview<\/span><\/a><\/span> <\/div>\n
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Maximize Efficiency with\u00a0Twin-Column\u00a0Technology<\/strong><\/h2>\n \n
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Multi-Dimensional Chromatography (2D\/3D)<\/h3>\n

\n Automate sequential purification across multiple columns and chemistries in a single run. ChromIQ\u00ae handles fraction transfer, timing, and method switching. <\/p>\n <\/div>\n

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Continuous Polishing (MCSGP)<\/h3>\n

\n Overlapping fractions are automatically recycled between twin columns, breaking the yield\u2013purity tradeoff. AutoPeak\u00ae dynamic control maintains performance cycle to cycle. <\/p>\n <\/div>\n

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Continuous Capture (CaptureSMB\u00ae)<\/h3>\n

\n Twin-column continuous loading maximizes resin utilization and throughput. AutomAb\u00ae dynamically controls breakthrough \u2014 adapting in real time to feed variability. <\/p>\n <\/div>\n

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Continuous Enrichment (N-Rich\u00ae)<\/h3>\n

\n Automated on-column enrichment of trace-level impurities from repeated injections. Replaces weeks of manual fraction pooling with a single unattended run. <\/p>\n <\/div>\n

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Dynamic Process Control (AutoPeak\u00ae & AutomAb\u00ae)<\/h3>\n

\n Real-time UV-based control that adapts your continuous process to feed and column variability \u2014 eliminating the need for fixed, conservative operating parameters. <\/p>\n <\/div>\n

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Scalable Purification Solutions from Lab to GMP<\/h2>\n
\n Seamlessly transfer your Contichrom\u00ae process from benchtop to production. Our integrated platform simplifies complex purifications to maximize yield, purity, and efficiency at every scale\u2014from R&D to commercial manufacturing. <\/div>\n