{"id":1934,"date":"2025-12-03T13:27:54","date_gmt":"2025-12-03T13:27:54","guid":{"rendered":"https:\/\/www.chromacon.com\/?post_type=application&p=1934"},"modified":"2026-05-10T16:19:58","modified_gmt":"2026-05-10T14:19:58","slug":"nutraceuticals-small-molecules","status":"publish","type":"application","link":"https:\/\/www.chromacon.com\/en\/applications\/nutraceuticals-small-molecules\/","title":{"rendered":"Small Molecules & Nutraceuticals"},"content":{"rendered":"
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\n Small Molecule Purification <\/p>\n \n

\n More Product. Less Solvent. MCSGP for Nutraceuticals<\/strong>.\n <\/h1>\n \n
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Higher yield, no re-chromatography. MCSGP<\/a> continuous polishing for cannabinoids, omega-3 fatty acids, steviol glycosides, flavonoids, and beyond \u2014 same RP-HPLC chemistry, same C18 columns, same solvents you already use. \u2502 52% \u2192 94%<\/strong> CBD yield at \u2264100 ppm THC \u2502 7.5\u00d7<\/strong> Productivity at equivalent purity \u2502 \u201330%<\/strong> Solvent consumption<\/p>\n

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Source: YMC ChromaCon Application Note (CBD purification from hemp extract, RP-HPLC)<\/em><\/p>\n <\/div>\n <\/div>\n\n

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\n Talk to Our Small Molecule Specialists<\/span><\/a><\/span> <\/div>\n
\n Download the CBD Application Note<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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\n Talk to Our Small Molecule Specialists<\/span><\/a><\/span> <\/div>\n
\n Download the CBD Application Note<\/span><\/a><\/span> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n\n
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\n The Natural Extract Purification Problem <\/h2>\n \n
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Demand for high-purity nutraceutical actives \u2014 pharmaceutical-grade CBD, ultra-pure EPA from fish oil, high-intensity sweeteners, botanical polyphenols \u2014 is growing rapidly. Chromatographic polishing is typically the final and most critical purification step. It must deliver both high purity and high yield from complex, variable natural extract feeds.<\/p>\n

Conventional batch RP-HPLC forces an impossible choice: hit purity specifications or recover maximum yield \u2014 not both.<\/strong> Natural extracts contain structurally similar co-eluting compounds (e.g., CBD with THC, EPA with DHA, Rebaudioside A with other steviol glycosides) that form the very impurity profile a center-cut must navigate. Narrow cuts achieve purity but sacrifice yield; wide cuts maximize recovery but fail purity specifications.<\/p>\n

The result: low-yield batch runs, costly re-chromatography, high solvent consumption, and excessive QC testing \u2014 all compressing margins in an already cost-sensitive market.<\/p>\n <\/div>\n \n <\/div>\n\n

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\n The Solution: MCSGP with AutoPeak\u00ae for Small Molecule Polishing <\/h2>\n \n
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MCSGP (Multi-column Countercurrent Solvent Gradient Purification) eliminates the purity-yield trade-off in small molecule and nutraceutical chromatography. Two identical reversed-phase columns continuously recycle impure side-fractions \u2014 recovering target compound that batch processes discard. It uses the same RP stationary phases, solvents, and gradients<\/strong> as your existing batch method.<\/p>\n

AutoPeak\u00ae dynamic process control monitors the elution profile in real-time via UV, automatically adjusting collection windows to maintain consistent purity output \u2014 enabling robust, unattended 24\/7 operation even when feed composition varies from batch to batch.<\/p>\n

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Same chemistry. Dramatically better results.<\/strong> MCSGP uses the same reversed-phase C18\/C8 resins, organic solvents, and gradient methods already used in your batch small molecule process \u2014 these existing conditions are the starting point for MCSGP development. No change to your resin or solvent chemistry is needed.<\/p>\n<\/blockquote>\n <\/div>\n \n Learn About MCSGP + AutoPeak\u00ae<\/span><\/a><\/span> <\/div>\n\n

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Proven Results: MCSGP vs. Batch Chromatography<\/h2>\n\n\n\n
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\n +80% <\/h2>\n \n

\n CBD Yield Increase (at 100 ppm THC)
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\n 7.5\u00d7 <\/h2>\n \n

\n Productivity Increase (at 1000 ppm THC) <\/p>\n \n \n <\/div>\n\n<\/div>\n\n <\/div><\/section><\/div>\n\n\n\n

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\n +250% <\/h3>\n \n

\n EPA-EE Yield Increase
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\n 6\u00d7 <\/h2>\n \n

\n EPA-EE Productivity Increase
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\n +334% <\/h3>\n \n

\n Crocin-I Recovery Increase
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